Commercialization of the hydrolytic kinetic resolution of racemic epoxides: toward the economical large-scale production of enantiopure epichlorohydrin

…, KE Hemberger, S Jasmin, H Kabir, P Morel

文献索引：Larrow, Jay F.; Hemberger, Karl E.; Jasmin, Serge; Kabir, Hocine; Morel, Phillipe Tetrahedron Asymmetry, 2003 , vol. 14, # 22 p. 3589 - 3592

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被引用次数: 64

摘要

The hydrolytic kinetic resolution of racemic terminal epoxides utilizing chiral (salen) Co (III) catalysts provides practical access to enantiopure epoxides and diols. However, general issues surrounding catalyst activation combined with the specific problem of racemization of epichlorohydrin served to make the large-scale production of (R)-or (S)-epichlorohydrin difficult and uneconomical. A process for the large-scale production and isolation of active ...