Tetrahedron letters

A progressive synthetic strategy for class B synergimycins

…, RE Taylor, LA Liotta, ML Bolla, EV Azevedo, I Medina…

文献索引：Robinson, Jennifer L.; Taylor, Rachel E.; Liotta, Lisa A.; Bolla, Megan L.; Azevedo, Enrique V.; Medina, Irene; McAlpine, Shelli R. Tetrahedron Letters, 2004 , vol. 45, # 10 p. 2147 - 2150

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被引用次数: 10

摘要

Described are the syntheses of four macrocyclic peptides that are the core structure of class B synergimycins, and the synthesis of a final class B derivative. Our synthetic route to these synergimycin derivatives allows the incorporation of amino acid substitutions at all points in the macrocycle, leading to structurally diverse class B analogs.