Use of tetrabutylammonium fluoride as a facile deprotecting reagent for 4-nitrobenzyl, 2, 2, 2-trichloroethyl, and phenacyl esters of amino acids

M Namikoshi, B Kundu, KL Rinehart

文献索引：Namikoshi, Michio; Kundu, Bijoy; Rinehart, Kenneth L. Journal of Organic Chemistry, 1991 , vol. 56, # 18 p. 5464 - 5466

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被引用次数: 34

摘要

13 10a DMF 9 10b 96+ 5.7+ 5.5 e 14 Cbz-Ala-OPac (lla) DMF 4 6b 98-19.7-20. ld a Abbreviations, see Text. 1= D isomer, 2-1 1= L isomer.* Measured before esterification unless otherwise noted. Dicyclohexylamine salt. dAnalyzed by chiral GC. eValue obtained after deprotection with Zn/AcOH. reagent for cleavage of a peptide chain from a resin support in solid-phase~ ynthesis.'l-'~ Recently, Nakata et al. have successfully used this ...