Selective deprotection of phenacyl, benzyl and methyl esters of N-protected amino acids and dipeptides and N-protected amino acids benzyl ester linked to resins with …

CJ Salomon, EG Mata, OA Mascaretti

文献索引：Salomon, Claudio J.; Mata, Ernesto G.; Mascaretti, Oreste A. Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 10 p. 995 - 999

全文：HTML全文

被引用次数: 13

摘要

Phenacyl, methyl and benzyl esters of variousN-α-Boc, N-α-Cbz or N, N-dimethylamino protected amino acids and dipeptides, as well as esters of N-α-protected amino acids linked to Wang and Pam resins have been efficiently and chemoselectively cleaved by bis (tributyltin) oxide in aprotic solvents to give the corresponding carboxylic acids in good yields. Moreover, the absence of racemization during the deprotection has been ...