Phenylhydrazide as an enzyme-labile protecting group in peptide synthesis

…, GH Müller, M Lehnig, H Waldmann

文献索引：Voelkert, Martin; Koul, Surrinder; Mueller, Gernot H.; Lehnig, Manfred; Waldmann, Herbert Journal of Organic Chemistry, 2002 , vol. 67, # 20 p. 6902 - 6910

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被引用次数: 21

摘要

The enzymatic cleavage of amino acid phenylhydrazides with the enzyme tyrosinase (EC 1.14. 18.1) offers a new, mild, and selective method for C-terminal deprotection of peptides. The advantages of the described methodology are the very mild oxidative removal of the protecting group at room temperature and pH 7, a high chemo-and regioselectivity, and the availability of the biocatalyst. Even in oxygen-saturated solution, the oxidation of sensitive ...

2018-66-8

N-苄氧羰基-L-亮氨酸

~21%

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~71%

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~9%

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~93%

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~26%

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~86%

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~66%

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~63%

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~98%

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~44%

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~87%

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Papain-catalyzed synthesis of phenylhydrazides of N-acylamin...

[Cerovsky, Vaclav; Jost, Karel Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 11 p. 2557 - 2561]