A model study on aromatase cytochrome P-450 reaction: transformation of androstene-3, 17, 19-trione to 10. beta.-hydroxyester-4-ene-3, 17-dione

Y Watanabe, Y Ishimura

文献索引：Watanabe, Yoshihito; Ishimura, Yuzuru Journal of the American Chemical Society, 1989 , vol. 111, # 20 p. 8047 - 8049

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被引用次数: 39

摘要

The remarkable reactivity of cytochrome P-450 is believed to derive from an oxoferryl porphyrin cation radical species, so called oxenoid, equivalent to compound I of peroxidase^.^^-^ If 5 is the intermediate responsible for the aromatization in the enzymatic system, the C-2 position of 4 must be more reactive than the (2-19 oxo group. However, oxidation of aldehydes to carboxylic acids by the oxenoid intermediate seems more likely ...