Iridium-Catalyzed α-Alkylation of Acetates with Primary Alcohols and Diols

Y Iuchi, Y Obora, Y Ishii

文献索引：Iuchi, Yosuke; Obora, Yasushi; Ishii, Yasutaka Journal of the American Chemical Society, 2010 , vol. 132, p. 2536 - 2537

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被引用次数: 55

摘要

Acetates were successfully alkylated with primary alcohols and α, ω-diols in the presence of tert-BuOK under the influence of [IrCl (cod)] 2. For instance, the reaction of tert-butyl acetate with n-butanol in the presence of tert-BuOK as a base and [IrCl (cod)] 2 as a catalyst in tert- BuOH at 100° C produced tert-butyl hexanoate in good yield. When the α, ω-diol 1, 9- nonanediol was employed, di-tert-butyl tridecanoate was obtained. These reactions are ...