Tetrahedron

Efficient Cs 2 CO 3-promoted solution and solid phase synthesis of carbonates and carbamates in the presence of TBAI

RN Salvatore, F Chu, AS Nagle, EA Kapxhiu, RM Cross…

文献索引：Salvatore, Ralph N; Chu, Feixia; Nagle, Advait S; Kapxhiu, Elona A; Cross, Richard M; Jung, Kyung Woon Tetrahedron, 2002 , vol. 58, # 17 p. 3329 - 3347

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被引用次数: 76

摘要

Novel solution and solid-phase methods for the synthesis of carbonates and carbamates were developed using cesium bases and TBAI via a three-component coupling. Cesium carbonate not only promoted successful carbonylations of alcohols and carbamations of amines, but also suppressed common side reactions traditionally seen using existing protocols. Various alcohols and amines were examined, using a wide array of alkyl ...