Tetrahedron Letters

An efficient and chemoselective Cbz-protection of amines using silica–sulfuric acid at room temperature

MB Gawande, V Polshettiwar, RS Varma…

文献索引：Gawande, Manoj B.; Polshettiwar, Vivek; Varma, Rajender S.; Jayaram, Radha V. Tetrahedron Letters, 2007 , vol. 48, # 46 p. 8170 - 8173

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被引用次数: 37

摘要

A simple, facile, and chemoselective N-benzyloxycarbonylation of amines using silica– sulfuric acid that proceeds under solvent-free conditions at room temperature has been achieved. These reactions are applicable to a wide variety of primary (aliphatic and cyclic) secondary amines, amino alcohols, and heterocyclic amines.