Steroids

Tetrapropylammonium perruthenate as a mild and efficient oxidant for sensitive steroidal alcohols

CK Acosta, PN Rao, HK Kim

文献索引：Acosta, C. Kirk; Rao, Pemmaraju N.; Kim, Hyun K. Steroids, 1993 , vol. 58, # 5 p. 205 - 208

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被引用次数: 18

摘要

Abstract Tetrapropylammonium perruthenate N-methylmorpholine N-oxide oxidation of steroidal alcohols is described. The reagent combination is mild and gave good yields of the corresponding ketones. Although the oxidation can generate ketones from 3-, 11-, 15-, 17-, and 20-hydroxy steroids, the oxidation of homoallylic alcohols proceeds in low yields. Finally, we observed that the oxidation reagents will convert 17α-hydroxy-2-keto steroids ...