Steroids

Oxidation of steroidal 5-en-3β-ols with Jones reagent in ether

BA Šolaja, DR Milić, LI Došen-Mićović

文献索引：Solaja, Bogdan A.; Mili, Dragana R.; Do, Ljiljana I. Steroids, 1994 , vol. 59, # 5 p. 330 - 334

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被引用次数: 21

摘要

Abstract The two-phase oxidation of steroidal 5-en-3β-ol (via 5-en-3-ones) into corresponding 4-en-3, 6-diones in diethyl ether with Jones reagent was investigated. It was found that the system Jones reagent/diethyl ether enables short reaction times and easy isolation of the obtained products. The exclusive abstraction of 4α-hydrogen during oxidation, together with molecular mechanics (MM2), and semiempirical (PM3) ...