Tetrahedron letters

Merrifield MicroTube TM reactors for solid phase synthesis

R Li, XY Xiao, AW Czarnik

文献索引：Li, Rongshi; Xiao, Xiao-Yi; Czarnik, Anthony W. Tetrahedron Letters, 1998 , vol. 39, # 47 p. 8581 - 8584

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被引用次数: 23

摘要

Polystyrene grafted polypropylene MicroTubeTM reactors (length× OD, 25× 5 mm) have been functionalized with chloromethyl groups (Merrifield-type) using chloromethyl methyl ether and Lewis acid catalysts. A potentiometric method using a chloride ion selective electrode has been developed to measure the loading of the Merrifield MicroTubeTM reactors. A typical loading of 25–35 μmol/tube for Merrifield MicroTubeTM reactors has ...