The Journal of Organic Chemistry

Solid-phase synthesis of biaryls via the Stille reaction

FW Forman, I Sucholeiki

文献索引：Forman, Frank W.; Sucholeiki, Irving Journal of Organic Chemistry, 1995 , vol. 60, # 3 p. 523 - 528

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被引用次数: 111

摘要

The solid-phase synthesis of biphenyls by heterogenous cross-coupling of trialkylphenylstannanes with aryl electrophiles is described. Tributylphenyltin attached by an amide bond to the Rink amide resin undergoes palladium-catalyzed coupling with aryl triflates and aryl iodides to produce after acid cleavage 4-biphenylacetamide in 3-15% yield. 4-Iodophenylacetic acid attached to the Rink amide resin by an amide bond also ...