Inhibitors of glycolic acid oxidase. 4-Substituted 3-hydroxy-1H-pyrrole-2, 5-dione derivatives

…, EJ Cragoe Jr, H Schwam, SR Michelson…

文献索引：Rooney; Randall; Streeter; Ziegler; Cragoe Jr.; Schwam; Michelson; Williams; Eichler; Duggan; Ulm; Noll Journal of Medicinal Chemistry, 1983 , vol. 26, # 5 p. 700 - 714

全文：HTML全文

被引用次数: 44

摘要

An extensive series of novel 4-substituted 3-hydroxy-lH-pyrrole-2, 5-dione derivatives has been prepared and studied as inhibitors of glycolic acid oxidase (GAO). Compounds possessing large lipophilic 4-substituents are, in general, potent, competitive inhibitors of porcine liver GAO in vitro. Methylation of the nitrogen or the 3-hydroxy substituent reduced potency dramatically, indicating the requirement for the two acidic functions on the lH- ...

59793-29-2

2-([1,1'-联苯]-4-...

63780-50-7

2-([1,1'-联苯]-4-基)乙酰胺

查看详情

~57%

查看详情

查看详情

查看详情

~87%

查看详情

~61%

查看详情

~45%

查看详情

查看详情

查看详情

~57%

查看详情

~62%

查看详情

查看详情

~50%

查看详情

查看详情

查看详情

~51%

查看详情

查看详情

查看详情

查看详情

~44%

查看详情

查看详情

查看详情

~46%

查看详情

查看详情

查看详情

~93%

查看详情

查看详情

Amidation of polyaromatic carboxylic acids in aqueous medium

[Maruyama, Reiji; Ono, Shin; Inoue, Masami Tetrahedron Letters, 2000 , vol. 41, # 27 p. 5229 - 5232]

Revolutionizing resin handling for combinatorial synthesis

[Atrash, Butrus Angewandte Chemie - International Edition, 2001 , vol. 40, # 5 p. 938 - 941]

Solid-phase synthesis of biaryls via the Stille reaction

[Forman, Frank W.; Sucholeiki, Irving Journal of Organic Chemistry, 1995 , vol. 60, # 3 p. 523 - 528]

Merrifield MicroTube TM reactors for solid phase synthesis

[Li, Rongshi; Xiao, Xiao-Yi; Czarnik, Anthony W. Tetrahedron Letters, 1998 , vol. 39, # 47 p. 8581 - 8584]