Binding interaction of quercetin-3-β-galactoside and its synthetic derivatives with SARS-CoV 3CL pro: Structure–activity relationship studies reveal salient …

…, C Luo, H Liu, W Xu, G Chen, OW Liew, W Zhu…

文献索引：Chen, Lili; Li, Jian; Luo, Cheng; Liu, Hong; Xu, Weijun; Chen, Gang; Liew, Oi Wah; Zhu, Weiliang; Puah, Chum Mok; Shen, Xu; Jiang, Hualiang Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 24 p. 8295 - 8306

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被引用次数: 65

摘要

The 3C-like protease (3CLpro) of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is one of the most promising targets for discovery of drugs against SARS, because of its critical role in the viral life cycle. In this study, a natural compound called quercetin-3-β-galactoside was identified as an inhibitor of the protease by molecular docking, SPR/FRET-based bioassays, and mutagenesis studies. Both molecular modeling ...