MPEP

Names

[ Name ]:
MPEP

[Synonym ]:
2-Methyl-6-(phenylethynyl)pyridine hydrochloride
MPEP,HCl
MFCD02262119
Pyridine, 2-methyl-6-(2-phenylethynyl)-, hydrochloride (1:1)
MPEP
2-Methyl-6-(phenylethynyl)pyridine hydrochloride (1:1)
2-methyl-6-phenylethynyl-pyridine
2-Methyl-6-phenylaethinyl-pyridin

Biological Activity

[Description]:

MPEP is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. IC50 value: 36 nMTarget: mGluR5Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. D'Souza, Manoranjan S.; Markou, Athina Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in rats.

[2]. Chau, Peipei; Soederpalm, Bo; Ericson, Mia The mGluR5 antagonist MPEP elevates accumbal dopamine and glycine levels; interaction with strychnine-sensitive glycine receptors. Addiction Biology (2011), 16(4), 591-599.

[3]. Inta, Dragos; Filipovic, Dragana; Lima-Ojeda, Juan M. et al. The mGlu5 receptor antagonist MPEP activates specific stress-related brain regions and lacks neurotoxic effects of the NMDA receptor antagonist MK-801: Significance for the use as anxiolytic/ant

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
336.3ºC at 760mmHg

[ Molecular Formula ]:
C₁₄H₁₁N

[ Molecular Weight ]:
193.24

[ Flash Point ]:
144.8ºC

[ PSA ]:
12.89000

[ LogP ]:
3.59180

[ Storage condition ]:
Desiccate at +4°C

Safety Information

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%