1-(4,4-diphenyl-3-butenyl)-3-piperidinecarboxylicacidhydrochloride;SKF89976AHCl
Names
[ CAS No. ]:
85375-15-1
[ Name ]:
1-(4,4-diphenyl-3-butenyl)-3-piperidinecarboxylicacidhydrochloride;SKF89976AHCl
[Synonym ]:
S1589_Selleck
1-(4,4-Diphenylbut-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride (1:1)
1-(4,4-Diphenyl-3-buten-1-yl)-3-piperidinecarboxylic acid hydrochloride (1:1)
3-Piperidinecarboxylic acid, 1-(4,4-diphenyl-3-buten-1-yl)-, hydrochloride (1:1)
SKF 89976A
SKF89976A (hydrochloride)
1-(4,4-diphenyl-3-butenyl)-3-piperidinecarboxylicacidhydrochloride;SKF89976AHCl
Biological Activity
[Description]:
[Related Catalog]:
[Target]
IC50: 0.28 μM (GAT-1), 137.34 μM (GAT-2), 202.8 μM (GAT-3)[1]
[In Vitro]
[In Vivo]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Boiling Point ]:
531.4ºC at 760 mmHg
[ Molecular Formula ]:
C22H26ClNO2
[ Molecular Weight ]:
371.90000
[ Flash Point ]:
275.2ºC
[ Exact Mass ]:
371.16500
[ PSA ]:
40.54000
[ LogP ]:
5.04490
[ Storage condition ]:
2-8℃
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ RIDADR ]:
NONH for all modes of transport
[ HS Code ]:
2933399090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933399090
[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Pharmacol. Biochem. Behav. 103(2) , 267-72, (2012)
The potency of anesthetics changes during development, probably due not only to pharmacokinetic factors such as differential distribution and/or metabolism, but also to pharmacodynamic factors such as...
Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A receptor channels.Epilepsia 47 , 706-716, (2006)
Stiripentol (STP) is currently an efficient drug for add-on therapy in infantile epilepsies because it improves the efficacy of antiepileptic drugs (AEDs) through its potent inhibition of liver cytoch...
Selective gating of glutamatergic inputs to excitatory neurons of amygdala by presynaptic GABAb receptor.Neuron 61(6) , 917-29, (2009)
GABAb receptor (GABAbR)-mediated suppression of glutamate release is critical for limiting glutamatergic transmission across the central nervous system (CNS). Here we show that, upon tetanic stimulati...