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(R)-ADX-47273

Names

[ CAS No. ]:
851881-59-9

[ Name ]:
(R)-ADX-47273

Biological Activity

[Description]:

(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation .

[Related Catalog]:

Research Areas >> Neurological Disease

[Target]

mGluR5:168 nM (EC50)


[In Vitro]

(R)-ADX-47273 (ADX-47273 (5)) is a potent mGluR5 positive allosteric modulator with an EC50 for potentiation of 168 nM and a 9-fold shift of the glutamate response curve at 1 μM[1].

[References]

[1]. Engers DW, et al. Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273. ChemMedChem. 2009 Apr;4(4):505-11.


[Related Small Molecules]

mavoglurant | L-Glutamine | CTEP (RO4956371) | LY 354740 | L-(+)Sodium glutamate | ADX-88178 | MPEP (Hydrochloride) | FITM | (S)-MCPG | Basimglurant | LY341495 | Dipraglurant | JNJ-40411813 | LY404039 | JNJ 16259685

Chemical & Physical Properties

[ Molecular Formula ]:
C20H17F2N3O2

[ Molecular Weight ]:
369.36

Related Compounds

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