m-PEG3-OMs

Names

[ CAS No. ]:
74654-05-0

[ Name ]:
m-PEG3-OMs

[Synonym ]:
triethyleneglycol monomethyl ether methanesulfonate

Biological Activity

[Description]:

m-PEG3-OMs is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₈H₁₈O₆S

[ Molecular Weight ]:
260.30500

[ Exact Mass ]:
260.09300

[ PSA ]:
110.67000

[ LogP ]:
0.24310

[ Storage condition ]:
-20°C

m-PEG3-OMs

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds