m-PEG3-azide

Names

[ Name ]:
m-PEG3-azide

[Synonym ]:
1-azido-triethylene glycol monomethyl ether
azidotriethylene glycol methyl ether
triethyleneglycol monomethyl ether azide
AmbotzPEG1219
1-Azido-3,6,9-trioxodecane

Biological Activity

[Description]:

m-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₇H₁₅N₃O₃

[ Molecular Weight ]:
189.21200

[ Exact Mass ]:
189.11100

[ PSA ]:
77.44000

[ LogP ]:
0.42906

m-PEG3-azide

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds