Tetraethylene glycol monomethyl ether

Names

[ Name ]:
Tetraethylene glycol monomethyl ether

[Synonym ]:
Tetraethyleneglycol monomethyl ether
MFCD00041756
2,5,8,11-Tetraoxatridecan-13-ol
3,6,9,12-tetraoxatridecan-1-ol
Methyl Tetraglycol
3,6,9,12-tetraoxatridecanol
DSSTox_CID_7829
Tetraethylene Glycol MonoMethyl Ether
EINECS 245-883-5
AmbotzPEG2155
methyltetraglycol

Biological Activity

[Description]:

Tetraethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
285.4±25.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₂₀O₅

[ Molecular Weight ]:
208.252

[ Flash Point ]:
126.4±23.2 °C

[ Exact Mass ]:
208.131073

[ PSA ]:
57.15000

[ LogP ]:
-1.87

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.436

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2909499000

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909499000

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Towards controlled polymer brushes via a self-assembly-assisted-grafting-to approach.

Nat. Commun. 7 , 11119, (2016)

Precise synthesis of polymer brushes to modify the surface of nanoparticles and nanodevices for targeted applications has been one of the major focuses in the community for decades. Here we report a s...

Related Compounds

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