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PNU 282987

Names

[ CAS No. ]:
711085-63-1

[ Name ]:
PNU 282987

[Synonym ]:
MFCD08703110

Biological Activity

[Description]:

PNU-282987 (free base) (Compound C7) is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 (free base) is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR
Signaling Pathways >> Neuronal Signaling >> nAChR
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT3 Receptor


[References]

[1]. Bodnar AL, Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem. 2005 Feb 24;48(4):905-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C14H17ClN2O

[ Molecular Weight ]:
264.75

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds