3-Methyladipic acid

Names

[ Name ]:
3-Methyladipic acid

[Synonym ]:
MFCD00002804
3-methylhexane-1,6-dioic acid
EINECS 221-293-3
3-Methylhexanedioic acid
3R-methyladipic acid
3-Methyladipic acid
3-methylhexanedioate
3-methyl-hexanedioic acid

Biological Activity

[Description]:

3-Methyladipic acid is the final metabolite in the ω-oxidation pathway.

[Related Catalog]:

Natural Products >> Acids and Aldehydes

Research Areas >> Metabolic Disease

[Target]

Human Endogenous Metabolite

[References]

[1]. Wierzbicki AS, et al. Refsum's disease: a peroxisomal disorder affecting phytanic acid alpha-oxidation. J Neurochem. 2002 Mar;80(5):727-35.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.197

[ Boiling Point ]:
341ºC

[ Melting Point ]:
95-97ºC

[ Molecular Formula ]:
C₇H₁₂O₄

[ Molecular Weight ]:
160.16800

[ Flash Point ]:
171ºC

[ Exact Mass ]:
160.07400

[ PSA ]:
74.60000

[ LogP ]:
0.96200

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2917190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2917190090

[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

2,6-Dimethyloctanedioic acid--a metabolite of phytanic acid in Refsum's disease.

Clin. Chem. 29(3) , 434-7, (1983)

The urine of two patients with Refsum's disease consistently contained 2,6-dimethyloctanedioic acid, a compound not normally found in human urine. In addition, their urines contained increased concent...

Metabolism of phytanic acid and 3-methyl-adipic acid excretion in patients with adult Refsum disease.

J. Lipid Res. 44(8) , 1481-8, (2003)

Adult Refsum disease (ARD) is associated with defective alpha-oxidation of phytanic acid (PA). omega-Oxidation of PA to 3-methyl-adipic acid (3-MAA) occurs although its clinical significance is unclea...

Supramolecular helical mesomorphic polymers. Chiral induction through H-bonding.

J. Am. Chem. Soc. 127(1) , 458-64, (2005)

The work described here concerns a challenge of general interest in supramolecular chemistry: the achievement of chiral helical organizations with controlled structures. This work provides a strategy ...