γ-Valerolactone

Names

[ CAS No. ]:
108-29-2

[ Name ]:
γ-Valerolactone

[Synonym ]:
γ-Valeryllactone
Pentanoic acid, 4-hydroxy-, .γ.-lactone
gamma-valerolactone
2(3H)-Furanone, dihydro-5-methyl-
(±)-4-Methylbutyrolactone
4-Valerolactone
Dihydro-5-methyl-2(3H)-furanone
4,5-Dihydro-5-methyl-2(3H)-furanone
(±)-γ-Valerolactone
Valeric acid, 4-hydroxy-, γ-lactone
EINECS 203-569-5
Valerolactone
Pentanoic acid, 4-hydroxy-, γ-lactone
5-methyldihydrofuran-2(3H)-one
2(3H)-Furanone, dihydro-5-methyl-, (±)-
5-Methyldihydro-2(3H)-furanone
furan-2-one, 5-methyltetrahydro-
dihydro-5-methyl-2(3H)-furanone,
γ-Valerolactone
MFCD00005400

Biological Activity

[Description]:

5-Methyldihydrofuran-2(3H)-one is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

[In Vitro]

γ-戊内酯是一种分析参考标准品，被归类为 γ-羟基戊酸的前药形式。1 本产品旨在用于研究和法医应用。

[References]

[1]. Andresen-Streichert, H., Jungen, H., Gehl, A., et al. Uptake of gamma-valerolactone--detection of gamma-hydroxyvaleric acid in human urine samples. J. Anal. Toxicol. 37(4), 250-254 (2013).

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
206.6±8.0 °C at 760 mmHg

[ Melting Point ]:
-31ºC

[ Molecular Formula ]:
C₅H₈O₂

[ Molecular Weight ]:
100.12

[ Flash Point ]:
81.1±0.0 °C

[ Exact Mass ]:
100.052429

[ PSA ]:
26.30000

[ LogP ]:
-0.27

[ Vapour density ]:
3.45 (vs air)

[ Vapour Pressure ]:
0.2±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.431

[ Water Solubility ]:
MISCIBLE

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LU3580000

CHEMICAL NAME :: 2(3H)-Furanone, dihydro-5-methyl-

CAS REGISTRY NUMBER :: 108-29-2

BEILSTEIN REFERENCE NO. :: 0080420

LAST UPDATED :: 199701

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C5-H8-O2

MOLECULAR WEIGHT :: 100.13

WISWESSER LINE NOTATION :: T5O CVTJ E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8800 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2480 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/m3/7H/92D-I

TOXIC EFFECTS :: Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

DOSE/DURATION :: 24400 ppm

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 201,431,1988

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36

[ Safety Phrases ]:
S26-S39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
LU3580000

[ Packaging Group ]:
I; II; III

[ HS Code ]:
29322980

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Isolation and characterization of rat intestinal bacteria involved in biotransformation of (-)-epigallocatechin.

Arch. Microbiol. 196(10) , 681-95, (2014)

Two intestinal bacterial strains MT4s-5 and MT42 involved in the degradation of (-)-epigallocatechin (EGC) were isolated from rat feces. Strain MT4s-5 was tentatively identified as Adlercreutzia equol...

Bioavailability and catabolism of green tea flavan-3-ols in humans

Nutrition 26(11-12) , 1110-6, (2010)

Objective The aim of this study was to investigate green tea flavan-3-ol catabolism and plasma pharmacokinetic and urinary excretion by high-performance liquid chromatography with tandem mass spectrom...

Nonenzymatic sugar production from biomass using biomass-derived γ-valerolactone.

Science 343(6168) , 277-80, (2014)

Widespread production of biomass-derived fuels and chemicals will require cost-effective processes for breaking down cellulose and hemicellulose into their constituent sugars. Here, we report laborato...

Related Compounds

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