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480-79-5

480-79-5结构式

常用中文名：全缘千里光碱
常用英文名：Integerrimine
CAS号：480-79-5
分子式：C₁₈H₂₅NO₅
分子量：335.39500
相关类别：研究领域炎症/免疫
发布时间：2018-08-13 09:24:25
更新时间：2024-01-09 11:53:08
(-)-整合子嘧啶,一种吡咯里西啶生物碱,具有抗溃疡活性。(-)-整合子亚胺也是果蝇中的一种致突变和弱致碎屑剂[1][2]。

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中文名	全緣千里光鹼
英文名	Pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-5,6-dimethyl(1,6)dioxacyclododecino(2,3,4-gh)
英文别名	Intergerrimine senecionyne Squalidine INTEGERRIMINE seneciionine 12-hydroxy-senecionane-11,16-dione

描述	(-)-整合子嘧啶,一种吡咯里西啶生物碱,具有抗溃疡活性。(-)-整合子亚胺也是果蝇中的一种致突变和弱致碎屑剂[1][2]。
相关类别	信号通路 >> 其他 >> 其他研究领域 >> 炎症/免疫
体外研究	(-)-整合子亚胺(0.00625-0.05 mM)在果蝇体细胞中也必须具有诱变活性。(-)-整合素亚胺通常需要细胞色素P450依赖性代谢激活来显示遗传毒性活性[1]。
参考文献	[1]. V R Campesato, et al. Recombinagenic activity of integerrimine, a pyrrolizidine alkaloid from Senecio brasiliensis, in somatic cells of Drosophila melanogaster. Environ Mol Mutagen. 1997;29(1):91-7. [2]. Walber Toma, et al. Modulation of gastrin and epidermal growth factor by pyrrolizidine alkaloids obtained from Senecio brasiliensis in acute and chronic induced gastric ulcers. Can J Physiol Pharmacol. 2004 May;82(5):319-25.

密度	1.25g/cm3
沸点	563.7ºC at 760 mmHg
熔点	172 °C
分子式	C₁₈H₂₅NO₅
分子量	335.39500
闪点	294.7ºC
精确质量	335.17300
PSA	76.07000
LogP	1.13070
蒸汽压	4.68E-15mmHg at 25°C
折射率	1.57
储存条件	-20°C，干燥，密封

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM9080000

CHEMICAL NAME :: Integerrimine

CAS REGISTRY NUMBER :: 480-79-5

LAST UPDATED :: 199603

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C18-H25-N-O5

MOLECULAR WEIGHT :: 335.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 78 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg/20D-I

TOXIC EFFECTS :: Related to Chronic Data - death

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 18750 ug/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 241,297,1990

危害码 (欧洲)	Xi
危险品运输编码	UN 1544
包装等级	III
危险类别	6.1(b)