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480-79-5

480-79-5 structure
480-79-5 structure
  • Name: Integerrimine
  • Chemical Name: Pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-5,6-dimethyl(1,6)dioxacyclododecino(2,3,4-gh)
  • CAS Number: 480-79-5
  • Molecular Formula: C18H25NO5
  • Molecular Weight: 335.39500
  • Catalog: Research Areas Inflammation/Immunology
  • Create Date: 2018-08-13 09:24:25
  • Modify Date: 2024-01-09 11:53:08
  • (-)-Integerrimine, a pyrrolizidine alkaloid, has antiulcerogenic activity. (-)-Integerrimine is also a mutagenic and weakly clastogenic agent in Drosophila[1][2].
Name Pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-5,6-dimethyl(1,6)dioxacyclododecino(2,3,4-gh)
Synonyms Intergerrimine
senecionyne
Squalidine
INTEGERRIMINE
seneciionine
12-hydroxy-senecionane-11,16-dione
Description (-)-Integerrimine, a pyrrolizidine alkaloid, has antiulcerogenic activity. (-)-Integerrimine is also a mutagenic and weakly clastogenic agent in Drosophila[1][2].
Related Catalog
In Vitro (-)-Integerrimine (0.00625-0.05 mM) also must have mutagenic activity in somatic cells of Drosophila. (-)-Integerrimine in general requires cytochrome P450-dependent metabolic activation to exhibit genotoxic activity[1].
References

[1]. V R Campesato, et al. Recombinagenic activity of integerrimine, a pyrrolizidine alkaloid from Senecio brasiliensis, in somatic cells of Drosophila melanogaster. Environ Mol Mutagen. 1997;29(1):91-7.

[2]. Walber Toma, et al. Modulation of gastrin and epidermal growth factor by pyrrolizidine alkaloids obtained from Senecio brasiliensis in acute and chronic induced gastric ulcers. Can J Physiol Pharmacol. 2004 May;82(5):319-25.
Density 1.25g/cm3
Boiling Point 563.7ºC at 760 mmHg
Melting Point 172 °C
Molecular Formula C18H25NO5
Molecular Weight 335.39500
Flash Point 294.7ºC
Exact Mass 335.17300
PSA 76.07000
LogP 1.13070
Vapour Pressure 4.68E-15mmHg at 25°C
Index of Refraction 1.57

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NM9080000
CHEMICAL NAME :
Integerrimine
CAS REGISTRY NUMBER :
480-79-5
LAST UPDATED :
199603
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C18-H25-N-O5
MOLECULAR WEIGHT :
335.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
78 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 mg/kg/20D-I
TOXIC EFFECTS :
Related to Chronic Data - death

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
18750 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 241,297,1990
Hazard Codes Xi
RIDADR UN 1544
Packaging Group III
Hazard Class 6.1(b)

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