480-78-4

• 常用中文名：阔叶千里光碱
• 常用英文名：Platyphylline
• CAS号：480-78-4
• 分子式：C₁₈H₂₇NO₅
• 分子量：337.41100
• 发布时间：2018-04-26 08:00:00
• 更新时间：2024-01-02 17:00:03

名称

• 中文名: 阔叶千里光碱
• 英文名: 12-Hydroxy-1,2-dihydrosenecionan-11,16-dione
• 中文别名: 闊葉千里光鹼
• 英文别名: Platyphylline; EINECS 207-558-6

物化性质

• 密度: 1.22 g/cm3
• 沸点: 539.6ºC at 760 mmHg
• 分子式: C₁₈H₂₇NO₅
• 分子量: 337.41100
• 闪点: 280.1ºC
• 精确质量: 337.18900
• PSA: 76.07000
• LogP: 1.21060
• 折射率: 1.553

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TP2518000 CHEMICAL NAME : Platyphylline CAS REGISTRY NUMBER : 480-78-4 LAST UPDATED : 199801 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C18-H27-N-O5 MOLECULAR WEIGHT : 337.46 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3100 mg/kg TOXIC EFFECTS : Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea REFERENCE : TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (1),34,1997 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 252 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AJEBAK Australian Journal of Experimental Biology and Medical Science. (Adelaide, S.A., Australia) V.1-64, 1924-86. Volume(issue)/page/year: 46,493,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 60 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - acute pulmonary edema Liver - hepatitis (hepatocellular necrosis), diffuse Blood - lymphoma, including Hodgkin's disease REFERENCE : RETOAE Research Today. (Indianapolis, IN) V.1-16, 1944-60. Discontinued. Volume(issue)/page/year: 5,53,1949 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2573 mg/kg TOXIC EFFECTS : Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea REFERENCE : TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (1),34,1997 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 577 mg/kg TOXIC EFFECTS : Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea REFERENCE : TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (1),34,1997 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 105 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - acute pulmonary edema Liver - hepatitis (hepatocellular necrosis), diffuse Blood - lymphoma, including Hodgkin's disease REFERENCE : RETOAE Research Today. (Indianapolis, IN) V.1-16, 1944-60. Discontinued. Volume(issue)/page/year: 5,53,1949 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5700 mg/kg/19D-I TOXIC EFFECTS : Liver - liver function tests impaired Related to Chronic Data - death REFERENCE : TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (1),34,1997

安全

• 危险品运输编码: UN 1544
• 包装等级: III
• 危险类别: 6.1(b)