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洛美沙星

洛美沙星用途

Lomefloxacin(SC47111A)是氟喹诺酮类抗生素。

洛美沙星名称

[ CAS 号 ]:
98079-51-7

[ 中文名 ]:
洛美沙星

[ 英文名 ]:
Lomefloxacin

[中文别名 ]:

[英文别名 ]:

LFLX
Lomefloxacin
Lomefloxacinum
Maxaquin
UNII:L6BR2WJD8V
Lomefloxacino
MFCD00242673
Lomefloxacine

洛美沙星生物活性

[ 描述 ]:

Lomefloxacin(SC47111A)是氟喹诺酮类抗生素。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[参考文献]

[1]. http://www.drugbank.ca/drugs/DB00978

[相关活性小分子]

洛美沙星物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
542.7±50.0 °C at 760 mmHg

[ 熔点 ]:
239-240ºC

[ 分子式 ]:
C₁₇H₁₉F₂N₃O₃

[ 分子量 ]:
351.348

[ 闪点 ]:
282.0±30.1 °C

[ 精确质量 ]:
351.139435

[ PSA ]:
74.57000

[ LogP ]:
1.71

[ 外观性状 ]:
灰白色至黄色晶体

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.566

[ 储存条件 ]:
−20°C

洛美沙星毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VB1997400

CHEMICAL NAME :: 3-Quinolinecarboxylic acid, 1,4-dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-pipera zinyl)-4-oxo-

CAS REGISTRY NUMBER :: 98079-51-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C17-H19-F2-N3-O3

MOLECULAR WEIGHT :: 351.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 24 mg/kg/3D-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3800 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - changes in motor activity (specific assay) Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 698 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 246 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA repair

TEST SYSTEM :: Bacteria - Bacillus subtilis

DOSE/DURATION :: 20 mg/L

REFERENCE :: AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 37,213,1993

洛美沙星安全信息

[ 危害码 (欧洲) ]:
Xn,Xi

[ 风险声明 (欧洲) ]:
22-36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ WGK德国 ]:
3

[ RTECS号 ]:
VB1997500

[ 海关编码 ]:
2933990090

洛美沙星合成路线

详细合成路线

洛美沙星上下游产品

洛美沙星上游产品

洛美沙星下游产品

洛美沙星制备

以2，3，4，5-氟苯甲酸为原料，经氯化亚砜氯化为酰氯，再和乙氧基丙二酸二乙酯缩合，然后脱羧生成四氟苯甲酰基乙酸乙酯，接着和原甲酸三乙脂在乙酸酐作用下缩合得到烯键，和乙胺反应以取代乙氧基，在氢化钠作用下环合生成喹啉环衍生物，酯基水解成羧基，最后和2-甲基哌嗪反应，得到洛美沙星。

洛美沙星海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%