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2-甲基哌嗪

2-甲基哌嗪用途

用于合成氧氟沙星、左氟沙星，加替沙星和喹诺酮类抗菌新药洛美沙星。

2-甲基哌嗪名称

[ CAS 号 ]:
109-07-9

[ 中文名 ]:
2-甲基哌嗪

[ 英文名 ]:
2-Methylpiperazine

[中文别名 ]:

2-甲基哌嗪

[英文别名 ]:

2-methyl-piperazin
Piperazine, 2-methyl-
2-Methylpiperazine
EINECS 203-644-2
Piperazine, 2-methyl-, (2S)-
PIPERAZINE,2-METHYL-
2-METHYLPIPERAZINE/LOMEFLOXCIN
2-METHYLPIPERAZIN
(rac)-2-methylpiperazine
UNII:D0LWN1061P

2-甲基哌嗪物理化学性质

[ 密度 ]:
0.8±0.1 g/cm3

[ 沸点 ]:
153.2±8.0 °C at 760 mmHg

[ 熔点 ]:
61-63 °C(lit.)

[ 分子式 ]:
C₅H₁₂N₂

[ 分子量 ]:
100.162

[ 闪点 ]:
45.1±10.2 °C

[ 精确质量 ]:
100.100044

[ PSA ]:
24.06000

[ LogP ]:
-0.68

[ 外观性状 ]:
白色晶体

[ 蒸汽压 ]:
3.4±0.3 mmHg at 25°C

[ 折射率 ]:
1.418

[ 储存条件 ]:
Flammables area

[ 水溶解性 ]:
78 g/100 mL (25 ºC)

2-甲基哌嗪MSDS

2-甲基哌嗪毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM1225020

CHEMICAL NAME :: Piperazine, 2-methyl-

CAS REGISTRY NUMBER :: 109-07-9

BEILSTEIN REFERENCE NO. :: 0383566

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C5-H12-N2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2030 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Kidney, Ureter, Bladder - other changes

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 1,58,1990

2-甲基哌嗪安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H228-H315-H319-H335

[ 警示性声明 ]:
P210-P261-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
F:Flammable

[ 风险声明 (欧洲) ]:
R11;R36/37/38

[ 安全声明 (欧洲) ]:
S16-S26-S36/37/39

[ 危险品运输编码 ]:
UN 1325 4.1/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
TM1225020

[ 包装等级 ]:
III

[ 危险类别 ]:
4.1

[ 海关编码 ]:
2933599090

2-甲基哌嗪合成路线

2-甲基哌嗪上下游产品

2-甲基哌嗪上游产品

2-甲基哌嗪下游产品

2-甲基哌嗪制备

1、以1,2-丙二胺和乙醇胺为原料 1,2-丙二胺与乙醇胺中通入氨气，高温加压下氢化制取。

2、以环氧丙烷与乙二胺为原料由环氧丙烷与乙二胺先制成N-（β-羟丙基）乙二胺后再闭环制取。

2-甲基哌嗪海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-甲基哌嗪文献

Induction of human leukemia cell differentiation via PKC/MAPK pathways by arsantin, a sesquiterpene lactone from Artemisia santolina.

Arch. Pharm. Res. 38 , 2020-8, (2015)

Sesquiterpene lactone compounds have received considerable attention in pharmacological research due to their therapeutic effects including anti-cancer and anti-inflammatory activities. In this report...

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