二氯乙酰氯

二氯乙酰氯用途

【用途一】
用于有机合成及农药、医药中间体
【用途二】
用作有机合成中间体
【用途三】
用于乙烯基杀虫剂的合成，还用于羊毛毡缩绒整理、漂白、脱色、保鲜、杀菌、消毒等。
【用途四】
用于乙烯基杀虫剂的合成，还用于羊毛毡缩绒整理；漂白；脱色；保鲜；杀菌；消毒等。

二氯乙酰氯名称

[ CAS 号 ]:
79-36-7

[ 中文名 ]:
二氯乙酰氯

[ 英文名 ]:
Dichloroacetyl chloride

[中文别名 ]:

[英文别名 ]:

Acetyl chloride, 2,2-dichloro-
Dichloroacetyl chloride
2,2-Dichloroacetyl chloride
EINECS 201-199-9
MFCD00000840

二氯乙酰氯物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
107.5±0.0 °C at 760 mmHg

[ 熔点 ]:
< 25ºC

[ 分子式 ]:
C₂HCl₃O

[ 分子量 ]:
147.388

[ 闪点 ]:
31.8±22.3 °C

[ 精确质量 ]:
145.909302

[ PSA ]:
17.07000

[ LogP ]:
1.27

[ 外观性状 ]:
无色至淡黄色冒烟的液体

[ 蒸汽压 ]:
27.0±0.2 mmHg at 25°C

[ 折射率 ]:
1.467

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 稳定性 ]:
Stable. Combustible. Incompatible with water, alcohols and oxidizing agents. Fumes in air.

[ 水溶解性 ]:
MAY DECOMPOSE

二氯乙酰氯MSDS

二氯乙酰氯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AO6650000

CHEMICAL NAME :: Acetyl chloride, dichloro-

CAS REGISTRY NUMBER :: 79-36-7

BEILSTEIN REFERENCE NO. :: 1209426

LAST UPDATED :: 199806

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C2-H-Cl3-O

MOLECULAR WEIGHT :: 147.38

WISWESSER LINE NOTATION :: GYGVG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2460 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2000 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 650 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 mg/kg/80W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 1 mg/plate

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 19(Suppl 21),2,1992

二氯乙酰氯安全信息

[ 符号 ]:

GHS05, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314-H400

[ 警示性声明 ]:
P273-P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R35;R50

[ 安全声明 (欧洲) ]:
S9-S26-S45-S61

[ 危险品运输编码 ]:
UN 1765 8/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
AO6650000

[ 包装等级 ]:
II

[ 危险类别 ]:
8

二氯乙酰氯合成路线

二氯乙酰氯上下游产品

二氯乙酰氯上游产品

二氯乙酰氯下游产品

二氯乙酰氯制备

制备方法中可采用多种工艺路线。二氯乙酸与氯磺酸的反应，氯仿与一氧化碳在无水三氯化铝催化下反应，二氯乙酸与光气在二甲基甲酰胺中反应，以及用三氯乙烯氧化等都可制得该品。三氯乙烯与偶氮二异丁腈（催化剂）加热至100℃，通入氧气，在0.6MPa压力下反应，维持油浴温度在110℃，反应10h，于常压下蒸出产品二氯乙酰氯。本反应副产物三氯环氧乙烷与甲胺、三乙胺、吡啶等胺类化合物反应亦可转化为二氯乙酰氯。

二氯乙酰氯文献

Halogenated derivatives QSAR model using spectral moments to predict haloacetic acids (HAA) mutagenicity.

Bioorg. Med. Chem. 16 , 5720-32, (2008)

The risk of the presence of haloacetic acids in drinking water as chlorination by-products and the shortage of experimental mutagenicity data for most of them requires a research work. This paper desc...

Autoimmune response in MRL+/+ mice following treatment with dichloroacetyl chloride or dichloroacetic anhydride.

Toxicol. Appl. Pharmacol. 216(2) , 248-55, (2006)

Dichloroacetyl chloride (DCAC) is formed from trichloroethene (TCE), which is implicated in inducing/accelerating autoimmune response. Due to its potent acylating activity, DCAC may convert proteins t...

Photocatalysis of gaseous trichloroethylene (TCE) over TiO2: the effect of oxygen and relative humidity on the generation of dichloroacetyl chloride (DCAC) and phosgene.

J. Hazard. Mater. 146(1-2) , 302-8, (2007)

Batch photocatalytic degradation of 80+/-2.5 ppm V trichloroethylene (TCE) was conducted to investigate the effect of the oxygen and relative humidity (RH) on the formation of the dichloroacetyl chlor...

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