四氯乙烷

四氯乙烷用途

【用途一】
用于生产金属净洗剂、杀虫剂、除草剂、溶剂等
【用途二】
用作溶剂及分析试剂
【用途三】
该品是有效的溶剂。但因毒性大，使这方面的用途受到限制。工业中主要用作三氯乙烯、四氯乙烯的原料。
【用途四】
用于有机合成。工业上用于生产金属净洗剂、杀虫剂、除草剂、溶剂等.校准仪器和装置；评价方法；工作标准；质量保证/质量控制；其他。

四氯乙烷名称

[ CAS 号 ]:
79-34-5

[ 中文名 ]:
四氯乙烷

[ 英文名 ]:
1,1,2,2-Tetrachloroethane

[中文别名 ]:

[英文别名 ]:

Westron
1,1,2,2-tetrachlorethan
MFCD00000848
Tetrachlorethane
1,1,2,2-Tetrachloroethane
s-Tetrachloroethane
Bonoform
Ethane,1,1,2,2-tetrachloro
tetrachloroethane
perchloroethylen

四氯乙烷物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
142.0±8.0 °C at 760 mmHg

[ 熔点 ]:
-43 °C

[ 分子式 ]:
C₂H₂Cl₄

[ 分子量 ]:
167.849

[ 闪点 ]:
42.6±15.8 °C

[ 精确质量 ]:
165.891068

[ LogP ]:
2.17

[ 外观性状 ]:
无色至淡黄色液体

[ 蒸汽密度 ]:
5.8 (vs air)

[ 蒸汽压 ]:
7.1±0.3 mmHg at 25°C

[ 折射率 ]:
1.480

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、食品添加剂分开存放

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, strong bases. Reacts violently with sodium, potassium, nitrates, 2,4-dinitrophenyl disulphide.

[ 水溶解性 ]:
0.3 g/100 mL (25 ºC)

四氯乙烷MSDS

四氯乙烷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KI8575000

CHEMICAL NAME :: Ethane, 1,1,2,2-tetrachloro-

CAS REGISTRY NUMBER :: 79-34-5

BEILSTEIN REFERENCE NO. :: 0969206

LAST UPDATED :: 199712

DATA ITEMS CITED :: 70

MOLECULAR FORMULA :: C2-H2-Cl4

MOLECULAR WEIGHT :: 167.84

WISWESSER LINE NOTATION :: GYGYGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 1000 mg/m3/30M

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - hallucinations, distorted perceptions

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1000 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4500 mg/m3/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 821 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1108 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Behavioral - ataxia

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Liver - hepatitis (hepatocellular necrosis), zonal Behavioral - sleep Liver - fatty liver degeneration

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 19 gm/m3/45M

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - general anesthetic Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Liver - fatty liver degeneration

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9480 mg/kg/6W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/m3/4H/6W-I

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16 gm/kg/40D-I

TOXIC EFFECTS :: Behavioral - sleep Liver - fatty liver degeneration Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 42 gm/kg/78W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 55 gm/kg/78W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 110 gm/kg/78W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: Mutation test systems - not otherwise specified

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 6.9 mg/m3 (1 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 20,477,1979 IARC Cancer Review:Human Inadequate Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,354,1987 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,354,1987 TOXICOLOGY REVIEW AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 40(3),A46,1979 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 5 ppm (35 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,249,1971 OSHA PEL (Gen Indu):8H TWA 5 ppm (35 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 5 ppm (35 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 5 ppm (35 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 5 ppm (35 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 1 ppm (7 mg/m3);Skin JAN 1993 OEL-AUSTRIA:TWA 1 ppm (7 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 1 ppm (6.9 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 1 ppm (7 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 1 ppm (7 mg/m3);STEL 3 ppm (21 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 1 ppm (7 mg/m3);STEL 5 ppm (35 mg/m3) JAN 1993 OEL-GERMANY:TWA 1 ppm (7 mg/m3);Skin;Carcinogen JAN 1993 OEL-JAPAN:TWA 1 ppm (6.9 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 1 ppm (7 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 5 ppm (35 mg/m3);Skin JAN 1993 OEL-POLAND:TWA 5 mg/m3 JAN 1993 OEL-RUSSIA:TWA 1 ppm JAN 1993 OEL-SWITZERLAND:TWA 1 ppm (7 mg/m3);Skin JAN 1993 OEL-TURKEY:TWA 5 ppm (35 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 1,1,2,2-TETRACHLOROETHANE-air:10H CA TWA 1 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 71460 No. of Facilities: 244 (estimated) No. of Industries: 8 No. of Occupations: 15 No. of Employees: 7044 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 71460 No. of Facilities: 501 (estimated) No. of Industries: 2 No. of Occupations: 10 No. of Employees: 4145 (estimated) No. of Female Employees: 926 (estimated)

四氯乙烷安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H331-H310-H370-H412

[ 警示性声明 ]:
P210-P260-P273-P280-P301 + P310-P302 + P350

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
T+:Verytoxic;N:Dangerous for the environment;

[ 风险声明 (欧洲) ]:
R26/27;R51/53

[ 安全声明 (欧洲) ]:
S38-S45-S61-S36/37

[ 危险品运输编码 ]:
UN 1702 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
KI8575000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

四氯乙烷合成路线

四氯乙烷上下游产品

四氯乙烷上游产品

四氯乙烷下游产品

四氯乙烷制备

由乙炔氯化制得。反应在四氯乙烷本身为溶剂下进行（气态乙炔和氯直接反应会发生爆炸），催化剂为五氯化锑或三氯化铁。当采用三氯化铁催化剂时，使系统保持负压，四氯乙烷处天回流状态，连续通入干燥的乙炔和氯气，反应热由回流的四氯乙烷蒸气吸收移走，收率为97%（对乙炔）。

四氯乙烷文献

QSPR modeling of octanol/water partition coefficient for vitamins by optimal descriptors calculated with SMILES.

Eur. J. Med. Chem. 43 , 714-40, (2008)

Simplified molecular input line entry system (SMILES) has been utilized in constructing quantitative structure-property relationships (QSPR) for octanol/water partition coefficient of vitamins and org...

Development of QSAR models for predicting hepatocarcinogenic toxicity of chemicals.

Eur. J. Med. Chem. 44 , 3658-64, (2009)

A dataset comprising 55 chemicals with hepatocarcinogenic potency indices was collected from the Carcinogenic Potency Database with the aim of developing QSAR models enabling prediction of the above u...

Simultaneous derivatization and solid-based disperser liquid-liquid microextraction for extraction and preconcentration of some antidepressants and an antiarrhythmic agent in urine and plasma samples followed by GC-FID.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 983-984 , 55-61, (2015)

The present work is based on a one-step method including derivatization and solid-based disperser liquid-liquid microextraction followed by gas chromatography-flame ionization detection (GC-FID) for t...

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