三氯乙酰氯

三氯乙酰氯用途

用途一：用作有机合成的重要原料，农药毒死蜱、甲基毒死蜱和除草剂的重要中间体
用途二：三氯乙酰氯在农药生产上用于合成有机磷杀虫剂毒死蜱、甲基毒死蜱的中间体三氯吡啶醇钠。
用途三：广泛用于合成广谱，高效杀虫、杀螨剂毒死蜱，甲基毒死蜱和除草剂的重要中间体。

三氯乙酰氯名称

[ CAS 号 ]:
76-02-8

[ 中文名 ]:
三氯乙酰氯

[ 英文名 ]:
Trichloroacetyl chloride

[中文别名 ]:

[英文别名 ]:

Trichloroacetochloride
Acetyl chloride, 2,2,2-trichloro-
Acetyl chloride, trichloro-
CCl3COCl
EINECS 200-926-7
TRICHLOROACETIC ACID CHLORIDE
Trichloroacetyl chloride [UN2442] [Corrosive]
MFCD00000792
Trichloroacetyl chloride
2,2,2-Trichloroethanoyl chloride

三氯乙酰氯物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
118.0±0.0 °C at 760 mmHg

[ 熔点 ]:
-57 °C

[ 分子式 ]:
C₂Cl₄O

[ 分子量 ]:
181.833

[ 闪点 ]:
31.0±26.5 °C

[ 精确质量 ]:
179.870331

[ PSA ]:
17.07000

[ LogP ]:
2.39

[ 外观性状 ]:
透明至略黄色冒烟的液体

[ 蒸汽压 ]:
17.0±0.2 mmHg at 25°C

[ 折射率 ]:
1.501

[ 储存条件 ]:
库房通风低温干燥,与碱、氧化剂分开存放

[ 稳定性 ]:
Stable. Reacts violently with water. Incompatible with alcohols, oxidizing agents, strong bases.

[ 水溶解性 ]:
reacts violently

三氯乙酰氯MSDS

三氯乙酰氯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AO7140000

CHEMICAL NAME :: Acetyl chloride, trichloro-

CAS REGISTRY NUMBER :: 76-02-8

BEILSTEIN REFERENCE NO. :: 0774120

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C2-Cl4-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,113,1982

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 475 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,113,1982

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 445 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,113,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7270 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1822 (estimated) No. of Female Employees: 272 (estimated)

三氯乙酰氯安全信息

[ 符号 ]:

GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H314-H330

[ 补充危害声明 ]:
Reacts violently with water.

[ 警示性声明 ]:
P260-P280-P284-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T+:Verytoxic;

[ 风险声明 (欧洲) ]:
R14;R22;R26;R29;R35

[ 安全声明 (欧洲) ]:
S26-S28-S36/37/39-S45-S8-S28A-S23

[ 危险品运输编码 ]:
UN 2442 8/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
AO7140000

[ 包装等级 ]:
II

[ 危险类别 ]:
8

[ 海关编码 ]:
2914700090

三氯乙酰氯合成路线

三氯乙酰氯上下游产品

三氯乙酰氯上游产品

三氯乙酰氯下游产品

三氯乙酰氯制备

三氯乙酰氯的合成方法较多，从原料来源、成本、工艺等方面综合考虑，工业上采用在催化剂存在下，由三氯乙酸和氯化亚砜进行酰氯化反应的路线。
在500L搪瓷反应釜中，加入约400kg熔融的三氯乙酸和适量催化剂，在搅拌下升温至80～100℃，慢慢滴加氯化亚砜350kg，生成的HCl和SO2气体，分别用水和碱液吸收。加完后回流4h，将生成的三氯乙酰氯蒸出，收集117～120℃淡黄色馏分，即为三氯乙酰氯产品，含量95％以上。由于三氯乙酰氯化学性质活泼，易发生水解和热分解等副反应，所以反应需在温度≤100℃和无水条件下进行。采用复合催化剂，可显著加快反应速度，提高酰氯化收率。另外，由于副产物氯化氢和二氧化硫会带出一部分氯化亚砜，所以氯化亚砜需适当过量。
从减少环境污染等方面考虑，也可在紫外线催化下，以四氯乙烯为原料，直接氧化合成三氯乙酰氯。CCl2=CCl2[O2, UV]→CCl3COCl

三氯乙酰氯海关

[ 海关编码 ]: 2914700090

[ 中文概述 ]:
2914700090 其他酮及醌的卤化、磺化衍生物（包括硝化和亚硝化衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

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