二溴甲烷

二溴甲烷用途

【用途一】
用作溶剂，也用于有机合成
【用途二】
用作有机合成原料，可作溶剂、制冷剂、阻燃剂和抗爆剂组分
【用途三】
二溴甲烷是制备杀菌剂腈菌唑和咪菌唑的原料。
【用途四】
有机合成原料。可作溶剂、致冷剂、阻燃剂和抗爆剂的组分；在医药工业上用作消毒剂和镇痛剂。还用于农药腈菌唑和其他有机合成等。

二溴甲烷名称

[ CAS 号 ]:
74-95-3

[ 中文名 ]:
二溴甲烷

[ 英文名 ]:
Dibromomethane

[中文别名 ]:

[英文别名 ]:

Dibromomethane
Methylenbromid
DBM
dibromo-methane
Dibrommethan
Methylene Bromide
METHYLENE DIBROMIDE
Methane,dibromo
CH2Br2
Methane, dibromo-

二溴甲烷物理化学性质

[ 密度 ]:
2.4±0.1 g/cm3

[ 沸点 ]:
97.0±0.0 °C at 760 mmHg

[ 熔点 ]:
-52 °C

[ 分子式 ]:
CH₂Br₂

[ 分子量 ]:
173.835

[ 闪点 ]:
-22.1±17.7 °C

[ 精确质量 ]:
171.852310

[ LogP ]:
1.54

[ 外观性状 ]:
无色液体

[ 蒸汽密度 ]:
6.05 (vs air)

[ 蒸汽压 ]:
48.7±0.1 mmHg at 25°C

[ 折射率 ]:
1.533

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、食品添加剂分开存放

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, aluminium, magnesium. Reacts violently with potassium.

[ 水溶解性 ]:
0.1 g/100 mL (20 ºC)

二溴甲烷MSDS

二溴甲烷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PA7350000

CHEMICAL NAME :: Methane, dibromo-

CAS REGISTRY NUMBER :: 74-95-3

BEILSTEIN REFERENCE NO. :: 0969143

LAST UPDATED :: 199710

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C-H2-Br2

MOLECULAR WEIGHT :: 173.85

WISWESSER LINE NOTATION :: E1E

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 108 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 40 gm/m3/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3738 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Rectal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 333 mg/kg/28D-C

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 1 umol/L

REFERENCE :: TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981- Volume(issue)/page/year: 13,205,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4051 No. of Facilities: 33 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 1065 (estimated) No. of Female Employees: 452 (estimated)

二溴甲烷安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H332-H412

[ 警示性声明 ]:
P273

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R20;R52/53

[ 安全声明 (欧洲) ]:
S24-S61-S45-S36/37-S16-S7

[ 危险品运输编码 ]:
UN 2664 6.1/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
PA7350000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2903399010

二溴甲烷合成路线

二溴甲烷上下游产品

二溴甲烷上游产品

二溴甲烷下游产品

二溴甲烷制备

1.三溴甲烷法　先用三氧化二砷和液碱反应，配制亚砷酸钠液。将亚砷酸钠液加热至65℃，在搅拌下徐徐加入溴仿，全部加完后继续搅拌回流4h，使反应完全，将反应物倾入5～6倍水中，吸出油状物，进行分馏。再用水洗至中性，用氯化钙脱水、精馏，得产品。

2.二氯甲烷法　在工业上尚有将无水CH2CL2在无水ALBr3催化下与HBr反应制取，同时还产生氯溴甲烷。

3.溴氯甲烷溴化氢法　反应式如下：

二溴甲烷海关

[ 海关编码 ]: 2903399010

[ 中文概述 ]:
2903399010 二溴甲烷。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最低关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: M.进口商品检验 N.出口商品检验

[ Summary ]:
2903399010 dibromomethane。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:5.5%。general tariff:30.0%

二溴甲烷文献

Synthesis and evaluation of candidate PET radioligands for corticotropin-releasing factor type-1 receptors.

Nucl. Med. Biol. 41(6) , 524-35, (2014)

A radioligand for measuring the density of corticotropin-releasing factor subtype-1 receptors (CRF1 receptors) in living animal and human brain with positron emission tomography (PET) would be a usefu...

Improved quality control of [18F]fluoromethylcholine.

Nucl. Med. Biol. 38(8) , 1143-8, (2011)

With respect to the broad application of [(18)F-methyl]fluorocholine (FCH), there is a need for a safe, but also efficient and convenient way for routine quality control of FCH. Therefore, a GC- metho...

Dimethylselenide as a probe for reactions of halogenated alkoxyl radicals in aqueous solution. Degradation of dichloro- and dibromomethane.

J. Phys. Chem. A 112(26) , 5908-16, (2008)

Using pulse radiolysis and steady-state gamma-radiolysis techniques, it has been established that, in air-saturated aqueous solutions, peroxyl radicals CH 2HalOO (*) (Hal = halogen) derived from CH 2C...

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