香芹酚
香芹酚用途
香芹酚名称
[ CAS 号 ]:
499-75-2
[ 中文名 ]:
香芹酚
[ 英文名 ]:
5-Isopropyl-2-methylphenol
[中文别名 ]:
[英文别名 ]:
- 5-Isopropyl-o-cresol
- 5-Isopropyl-2-Methylphenol
- 2-methyl-5-(1-methylethyl)phenol
- EINECS 207-889-6
- MFCD00002236
- 2-methyl-5-propan-2-ylphenol
香芹酚生物活性
[ 描述 ]:
[ 相关类别 ]:
[参考文献]
香芹酚物理化学性质
[ 密度 ]:
1.0±0.1 g/cm3
[ 沸点 ]:
237.2±9.0 °C at 760 mmHg
[ 熔点 ]:
3-4 °C(lit.)
[ 分子式 ]:
C10H14O
[ 分子量 ]:
150.218
[ 闪点 ]:
106.7±0.0 °C
[ 精确质量 ]:
150.104462
[ PSA ]:
20.23000
[ LogP ]:
3.28
[ 外观性状 ]:
无色或淡黄色液体
[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C
[ 折射率 ]:
1.523
[ 储存条件 ]:
库房低温通风干燥,防明火,高温,与氧化剂分开存放
[ 稳定性 ]:
Stable. Combustible. Incompatible with strong bases, strong oxidizing agents.
[ 水溶解性 ]:
Insoluble
香芹酚MSDS
香芹酚毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- FI1225000
- CHEMICAL NAME :
- Carvacrol
- CAS REGISTRY NUMBER :
- 499-75-2
- BEILSTEIN REFERENCE NO. :
- 1860514
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 13
- MOLECULAR FORMULA :
- C10-H14-O
- MOLECULAR WEIGHT :
- 150.24
- WISWESSER LINE NOTATION :
- QR B1 EY1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,743,1979 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 810 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 73300 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia
- REFERENCE :
- QJDRAZ Quarterly Journal of Crude Drug Research. (Lisse, Netherlands) V.1-19, 1961-81. For publisher information, see IJCREE. Volume(issue)/page/year: 19,1,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 680 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- SIZSAR Sapporo Igaku Zasshi. Sapporo Medical Journal. (Sapporo Igaku Daigaku, Nishi-17-chome, Minami-1-jo, Chuo-ku, Sapporo 060, Japan) V.3- 1952- Volume(issue)/page/year: 3,73,1952
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Behavioral - sleep
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 23,1350,1980
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 310 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 3,109,1948
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 5,46,1959
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 161,196,1931
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2700 mg/kg
- TOXIC EFFECTS :
- Skin and Appendages - dermatitis, other (after systemic exposure)
- REFERENCE :
- JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 38,366,1949
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 5,46,1959
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Amphibian - frog
- DOSE/DURATION :
- 75 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 5,46,1959 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5071 No. of Facilities: 1235 (estimated) No. of Industries: 6 No. of Occupations: 8 No. of Employees: 7449 (estimated) No. of Female Employees: 979 (estimated)
香芹酚安全信息
[ 符号 ]:
GHS05, GHS07
[ 信号词 ]:
Danger
[ 危害声明 ]:
H302-H314
[ 警示性声明 ]:
P280-P305 + P351 + P338-P310
[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
C:Corrosive
[ 风险声明 (欧洲) ]:
R22;R34
[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45
[ 危险品运输编码 ]:
UN 3265 8/PG 3
[ WGK德国 ]:
3
[ RTECS号 ]:
FI1225000
[ 包装等级 ]:
III
[ 危险类别 ]:
8
[ 海关编码 ]:
2907199090
香芹酚合成路线
香芹酚上下游产品
香芹酚上游产品
香芹酚下游产品
香芹酚制备
1.从牛至油、百里香油用碱液制成酚盐将其单离出来。
2.用对伞花烃经磺化成相应的,对伞花烃-2-磺酸,然后经碱熔处理转化为所需的产品。
3.单离法 用酚钠盐从百里香油中单离出百里酚。
4.合成法 以薄荷脑为原料,在铜、镍催化剂存在下脱氢而成。
5.也可从丙烯出发与间甲酚缩合而成。
6.由多种中草药经提取加工而成。
香芹酚海关
[ 海关编码 ]: 2907199090
[ 中文概述 ]:
2907199090 其他一元酚. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2907199090 other monophenols VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
香芹酚文献
Life Sci. 116(1) , 8-15, (2014)
The present study evaluated the carvacrol (CARV) effect on hyperalgesia and nociception induced by sarcoma 180 (S180) in mice.Carvacrol treatment (12.5-50mg/kgs.c.) once daily for 15days was started 2...
Comparison of biological processes induced in HepG2 cells by tert-butyl hydroperoxide (t-BHP) and hydroperoxide (H2O2): The influence of carvacrol.Mutat. Res. 757(1) , 15-22, (2013)
This paper presents comparisons of biological impacts of the oxidants H2O2 and t-BHP on human liver cells, and shows modulation of these effects by the phenolic compound carvacrol. To understand bette...
Activity of essential oil of Lippia triplinervis Gardner (Verbenaceae) on Rhipicephalus microplus (Acari: Ixodidae).Parasitol. Res. 112(2) , 863-9, (2013)
The objective of this work was to characterize and investigate the acaricidal activity of the essential oil of the aerial parts of Lippia triplinervis at different concentrations on unengorged larvae ...
相关化工产品/化学物质:
推荐生产厂家/供应商:
公司名:南通润丰石油化工有限公司
区域:南通市崇川区
价格:
¥需询单/1kg
¥需询单/1ton
联系人:曹经理
产品详情:香芹酚
公司名:上海吉至生化科技有限公司
区域:上海市奉贤区
价格:
¥298.0/50mg
¥808.0/500g
¥108.0/100g
联系人:刘佳
产品详情:香荆芥酚
公司名:上海脉铂医药科技有限公司
区域:上海市嘉定区
价格:
¥389.0/50mg
¥需询单/1g
¥需询单/1g
¥需询单/1g
联系人:李先生
产品详情:Carvacrol
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥205.9/1ml
¥123.9/100g
¥53.9/25g
¥1696.9/3kg
联系人:阿拉丁李高志
产品详情:香芹酚
公司名:上海创赛科技有限公司
区域:上海市嘉定区
价格:
¥57.0/25g
¥125.0/100g
¥573.0/500g
¥2196.0/2500g
联系人:夏言
产品详情:[Perfemiker]香芹酚,99%
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香芹酚相关知识
2022-04-17 19:58:01
“香芹酚”:天然植物精油抑菌剂 美国农业部的“植物化学和植物物种学”背景资料表明,牛至含有30多种抑菌化合物,这些成分里面抑菌能力最好的是香芹酚和百里香酚,不但可以杀死真菌或阻止其生长,同时可以抑制多数细菌的生长,而且这种非特异性的抗菌作用不会让细菌产生抗药性。牛至精油中香芹酚是抵抗有害微生物和...
相关化合物
【香芹酚】化源网提供香芹酚CAS号499-75-2,香芹酚MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询香芹酚上化源网,专业又轻松。>>电脑版:香芹酚
标题:香芹酚_MSDS_用途_密度_香芹酚CAS号【499-75-2】_化源网 地址:https://www.chemsrc.com/amp/cas/499-75-2_946817.html