乙酰紫草素

乙酰紫草素用途

Acetylshikonin,来源于紫草根,具有抗癌、抗炎作用。Acetylshikonin 是一种非选择性的细胞色素 P450 抑制剂,对所有 P450 亚型抑制的 IC50 值范围为 1.4-4.0 μM。Acetylshikonin 是一种 AChE 抑制剂,具有很强的抗凋亡活性。

乙酰紫草素名称

[ CAS 号 ]:
24502-78-1

[ 中文名 ]:
乙酰紫草素

[ 英文名 ]:
Acetylshikonin

[英文别名 ]:

1'O-acetylshikonin
O-Acetylshikonin
Shikonin acetate
acethylshikonin
Shikonin,acetyl
MFCD00143538
acetyl shikonin

乙酰紫草素生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450

研究领域 >> 炎症/免疫

信号通路 >> 神经信号通路 >> 疼痛

[ 靶点 ]

IC50: 1.4-4.0 μM (all P450s)[2] AChE[3]

[参考文献]

[1]. Park SH, et al. Identification of acetylshikonin as the novel CYP2J2 inhibitor with anti-cancer activity in HepG2 cells. Phytomedicine. 2017 Jan 15;24:134-140.

[2]. Shon JC, et al. Acetylshikonin is a novel non-selective cytochrome P450 inhibitor. Biopharm Drug Dispos. 2017 Dec;38(9):553-556.

[3]. Wang Y, et al. Acetylshikonin, a Novel AChE Inhibitor, Inhibits Apoptosis via Upregulation of Heme Oxygenase-1 Expression in SH-SY5Y Cells. Evid Based Complement Alternat Med. 2013;2013:937370.

乙酰紫草素物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
553.2±50.0 °C at 760 mmHg

[ 熔点 ]:
86°C

[ 分子式 ]:
C₁₈H₁₈O₆

[ 分子量 ]:
330.332

[ 闪点 ]:
201.3±23.6 °C

[ 精确质量 ]:
330.110352

[ PSA ]:
100.90000

[ LogP ]:
4.57

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.602

[ 储存条件 ]:
室温，干燥，密封

乙酰紫草素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QL8001000

CHEMICAL NAME :: 1,4-Naphthoquinone, 5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-, 2-acetate, (+)-

CAS REGISTRY NUMBER :: 24502-78-1

LAST UPDATED :: 199112

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C18-H18-O6

MOLECULAR WEIGHT :: 330.36

WISWESSER LINE NOTATION :: L66 BV EVJ CYOV1&2UY1&1 GQ JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 73,193,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 41 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - ataxia

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 73,193,1977

乙酰紫草素

乙酰紫草素用途

乙酰紫草素名称

乙酰紫草素生物活性

乙酰紫草素物理化学性质

乙酰紫草素毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

乙酰紫草素安全信息

乙酰紫草素合成路线

详细合成路线

乙酰紫草素上下游产品

乙酰紫草素上游产品

乙酰紫草素下游产品

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