(+/-)-尼古丁
(+/-)-尼古丁用途
用于生化研究及园艺杀虫剂。
(+/-)-尼古丁名称
[ CAS 号 ]:
22083-74-5
[ 中文名 ]:
(+/-)-尼古丁
[ 英文名 ]:
(±)-nicotine
[中文别名 ]:
[英文别名 ]:
- vrzjvuppqwdfac-yhyxmxqvsa
- (R,S)-nicotine
- (RS)-nicotine
- 3-(1-Methyl-2-pyrrolidinyl)pyridine
- fdhr
- 3-(1-methyl-2-pyrrolidinyl)-Pyridine
- 1-Methyl-2-(3-pyridyl)pyrrolidine
- MFCD00065370
- (+/-)-nicotine
- Pyridine, 3-(1-methyl-2-pyrrolidinyl)-
(+/-)-尼古丁物理化学性质
[ 密度 ]:
1.0±0.1 g/cm3
[ 沸点 ]:
244.4±28.0 °C at 760 mmHg
[ 熔点 ]:
-79ºC
[ 分子式 ]:
C10H14N2
[ 分子量 ]:
162.232
[ 闪点 ]:
101.7±0.0 °C
[ 精确质量 ]:
162.115692
[ PSA ]:
16.13000
[ LogP ]:
0.72
[ 外观性状 ]:
liquid | yellow
[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C
[ 折射率 ]:
1.539
[ 储存条件 ]:
Refrigerator
[ 水溶解性 ]:
ethanol: 50 mg/mL
(+/-)-尼古丁毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QS5257500
- CHEMICAL NAME :
- Nicotine, (+-)-
- CAS REGISTRY NUMBER :
- 22083-74-5
- BEILSTEIN REFERENCE NO. :
- 0082111
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C10-H14-N2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 31250 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 50,93,1934
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 50,93,1934
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 2 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 50,93,1934
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 15 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 50,93,1934
(+/-)-尼古丁安全信息
[ 符号 ]:
GHS06, GHS09
[ 信号词 ]:
Danger
[ 危害声明 ]:
H301-H310-H411
[ 警示性声明 ]:
P273-P280-P301 + P310-P302 + P350-P310
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
T+: Very toxic;N: Dangerous for the environment;
[ 风险声明 (欧洲) ]:
25-27-51/53
[ 安全声明 (欧洲) ]:
36/37-45-61
[ 危险品运输编码 ]:
UN 1654 6.1/PG 2
[ WGK德国 ]:
3
[ RTECS号 ]:
QS5257500
(+/-)-尼古丁合成路线
(+/-)-尼古丁上下游产品
(+/-)-尼古丁上游产品
(+/-)-尼古丁下游产品
(+/-)-尼古丁制备
将烟叶和石灰石一起蒸馏后，再以乙醚萃取而得。
(+/-)-尼古丁文献
Eur. J. Neurosci. 41(1) , 109-19, (2015)
Rats raised in an enriched condition (EC) exhibit alterations in the neurobiological and behavioral response to nicotine compared with rats reared in an impoverished condition (IC) or a standard condi...
Effects of maternal nicotine exposure on thyroid hormone metabolism and function in adult rat progeny.J. Endocrinol. 224(3) , 315-25, (2015)
Postnatal nicotine exposure leads to obesity and hypothyroidism in adulthood. We studied the effects of maternal nicotine exposure during lactation on thyroid hormone (TH) metabolism and function in a...
A critical role for the melanocortin 4 receptor in stress-induced relapse to nicotine seeking in rats.Addict. Biol. 20(2) , 324-35, (2015)
Tobacco addiction is characterized by a lack of control over smoking and relapse after periods of abstinence. Smoking cessation leads to a dysphoric state that contributes to relapse to smoking. After...
推荐生产厂家/供应商：
相关化合物
【(+/-)-尼古丁】化源网提供(+/-)-尼古丁CAS号22083-74-5，(+/-)-尼古丁MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询(+/-)-尼古丁上化源网，专业又轻松。>>电脑版：(+/-)-尼古丁
标题：(+/-)-尼古丁_用途_密度_熔点_CAS号【22083-74-5】_化源网 地址：https://www.chemsrc.com/amp/cas/22083-74-5_599872.html