麦斯明
麦斯明用途
麦斯明名称
[ CAS 号 ]:
532-12-7
[ 中文名 ]:
麦司明
[ 英文名 ]:
Myosmine
[中文别名 ]:
[英文别名 ]:
- Prestwick_202
- 3-(4,5-dihydro-3H-pyrrol-2-yl)-pyridine
- Pyridine, 3-(1-pyrrolin-2-yl)-
- dehydronornicotine
- 3-(3,4-Dihydro-2H-pyrrol-5-yl)pyridine
- Pyridine, 3-(3,4-dihydro-2H-pyrrol-5-yl)-
- MFCD00052019
- 3-(1-Pyrrolin-2-yl)pyridine
- Myosmine
- Pyridine,3-(3,4-dihydro-2H-pyrrol-5-yl)
麦斯明生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
Ki: 3300 nM (a4b2 nAChR) and >10 µM (AT1)[1]
[体外研究]
[体内研究]
[参考文献]
麦斯明物理化学性质
[ 密度 ]:
1.1±0.1 g/cm3
[ 沸点 ]:
244.7±22.0 °C at 760 mmHg
[ 熔点 ]:
42-44°C
[ 分子式 ]:
C9H10N2
[ 分子量 ]:
146.189
[ 闪点 ]:
101.8±22.3 °C
[ 精确质量 ]:
146.084396
[ PSA ]:
25.25000
[ LogP ]:
-0.63
[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C
[ 折射率 ]:
1.611
[ 储存条件 ]:
2-8°C
[ 稳定性 ]:
Moisture, Temperature Sensitive
麦斯明毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UT7660000
- CHEMICAL NAME :
- Pyridine, 3-(1-pyrrolin-2-yl)-
- CAS REGISTRY NUMBER :
- 532-12-7
- BEILSTEIN REFERENCE NO. :
- 0119254
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C9-H10-N2
- MOLECULAR WEIGHT :
- 146.21
- WISWESSER LINE NOTATION :
- T6NJ C- BT5N AUTJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1875 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 63,423,1946
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 190 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 63,423,1946
麦斯明安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H302-H315-H319-H335
[ 警示性声明 ]:
P261-P305 + P351 + P338
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves
[ 危害码 (欧洲) ]:
Xn
[ 风险声明 (欧洲) ]:
R22
[ 安全声明 (欧洲) ]:
S26-S36
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
3
[ RTECS号 ]:
UT7660000
[ 海关编码 ]:
2933990090
麦斯明合成路线
麦斯明上下游产品
麦斯明上游产品
麦斯明下游产品
麦斯明海关
[ 海关编码 ]: 2933990090
[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
麦斯明文献
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 997 , 142-5, (2015)
A reversed-phase HPLC-UV method was developed, optimized, and validated for the separation and quantitation of six target alkaloids from leaves of Nicotiana species (nicotine, nornicotine, anatabine, ...
Effects of nicotine and minor tobacco alkaloids on intracranial-self-stimulation in rats.Drug Alcohol Depend. 153 , 330-4, (2015)
While nicotine is the primary addictive compound in tobacco, other tobacco constituents including minor alkaloids (e.g., nornicotine, anabasine) may also contribute to tobacco addiction by mimicking o...
Low-dose nicotine self-administration is reduced in adult male rats naïve to high doses of nicotine: implications for nicotine product standards.Exp. Clin. Psychopharmacol. 22(5) , 453-9, (2014)
Product standards that greatly reduce the content of nicotine within cigarettes may result in improved public health. The study presented here used an animal model to investigate whether individuals w...
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联系人:朱丽丹
产品详情:麦斯明
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相关化合物
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