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甲磺酸沙奎那韦

甲磺酸沙奎那韦用途

Saquinavir甲磺酸盐是HIV蛋白酶抑制剂,用于逆转录病毒治疗。

甲磺酸沙奎那韦名称

[ CAS 号 ]:
149845-06-7

[ 中文名 ]:
甲磺酸沙奎拉韦

[ 英文名 ]:
Saquinavir mesylate

[中文别名 ]:

[英文别名 ]:

Saquinavir mesilate
Saquinavir monomethanesulfonate salt
Saquinavir Mesylate
MFCD00944907

甲磺酸沙奎那韦生物活性

[ 描述 ]:

Saquinavir甲磺酸盐是HIV蛋白酶抑制剂,用于逆转录病毒治疗。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> 代谢酶/蛋白酶 >> HIV蛋白酶

信号通路 >> 抗感染 >> HIV

研究领域 >> 感染

[参考文献]

[1]. Kaldor et al (1995) Isophthalic acid derivatives: amino acid surrogates for the inhibition of HIV-1 protease. Bioorg.Med.Chem.Lett. 5 721.

[2]. Yerino GA, Halabe EK, Zini E, Feleder EC.Bioequivalence study of two oral tablet formulations containing saquinavir mesylate boosted with ritonavir in healthy male subjects.Arzneimittelforschung. 2011;61(8):481-7.

[3]. Branham ML, Moyo T, Govender T.Preparation and solid-state characterization of ball milled saquinavir mesylate for solubility enhancement.Eur J Pharm Biopharm. 2012 Jan;80(1):194-202.

[4]. Brouwers J, Vermeire K, Grammen C, Schols D, Augustijns P.Early identification of availability issues for poorly water-soluble microbicide candidates in biorelevant media: a case study with saquinavir.Antiviral Res. 2011 Aug;91(2):217-23.

[5]. Knechten H, Lutz T, Pulik P, Martin T, Tappe A, Jaeger H.Safety and Efficacy in HIV-1-Infected Patients Treated with Ritonavir-Boosted Saquinavir Mesylate.

[相关活性小分子]

甲磺酸沙奎那韦物理化学性质

[ 沸点 ]:
1015ºC at 760 mmHg

[ 分子式 ]:
C₃₉H₅₄N₆O₈S

[ 分子量 ]:
766.946

[ 闪点 ]:
567.7ºC

[ 精确质量 ]:
766.372375

[ PSA ]:
229.50000

[ LogP ]:
5.48810

[ 外观性状 ]:
白色或淡黄色粉末

[ 蒸汽压 ]:
0mmHg at 25°C

[ 储存条件 ]:
-20°C Freezer

甲磺酸沙奎那韦MSDS

详细MSDS(安全技术说明书)

甲磺酸沙奎那韦安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

甲磺酸沙奎那韦上下游产品

甲磺酸沙奎那韦上游产品

甲磺酸沙奎那韦下游产品

甲磺酸沙奎那韦文献

Intranasal in situ gel loaded with saquinavir mesylate nanosized microemulsion: preparation, characterization, and in vivo evaluation.

Int. J. Pharm. 475(1-2) , 191-7, (2014)

Saquinavir mesylate (SM) is a protease inhibitor with activity against human immunodeficiency virus type 1 (HIV-1) and is available in tablet form, which has three major problems. First, the drug unde...

Saquinavir-NO-targeted S6 protein mediates sensitivity of androgen-dependent prostate cancer cells to TRAIL.

Cell Cycle 11(6) , 1174-82, (2012)

We previously reported that the NO-modified form of HIV protease inhibitor Saquinavir (Saq) is a potent antitumoral agent efficient against numerous tumor cell lines in vitro and in vivo. In acute tox...

Can inhibition of proteasomes or NF-kappaB help control idiopathic nephrotic syndrome?

Nephrol. Dial. Transplant. 27(5) , 1698-701, (2012)

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