N-甲基吗啉

N-甲基吗啉用途

【用途一】
用作溶剂、催化剂、乳化剂、有机合成中间体等
【用途二】
用于有机合成及制药工业，也用作气相色谱固定液
【用途三】
N-甲基吗啉是植物生长调节剂调节安的中间体。
【用途四】
用于萃取溶剂、氯烃类的稳定剂、阻蚀剂、催化剂、药物的生产。
【用途五】
在聚氨酯行业，N-甲基吗啉（109-02-4）用作聚酯型聚氨酯软块泡的催化剂。N-甲基吗啉（109-02-4）还用作溶剂、催化剂、腐蚀抑制剂等，也用于橡胶促进剂和其他精细化学品的合成，用作合成氨基苄青霉素和基苄基青霉素的催化剂。用双氧水氧化N-甲基吗啉可制造N-甲基氧化吗啉。
【用途六】
萃取溶剂，催化剂，腐蚀抑制剂、分析试剂及药品制造等

N-甲基吗啉名称

[ CAS 号 ]:
109-02-4

[ 中文名 ]:
N-甲基吗啡啉

[ 英文名 ]:
4-methylmorpholine

[中文别名 ]:

[英文别名 ]:

1-Methylmorpholine
Morpholine,N-methyl
Morpholine,4-methyl
Methylmorpholine
EINECS 203-640-0
N-Me-morpholine
4-Methylmorfolin
MFCD00006175
4-methyl morpholine
N-Methyl morpholine

N-甲基吗啉物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
114.1±15.0 °C at 760 mmHg

[ 熔点 ]:
−66 °C(lit.)

[ 分子式 ]:
C₅H₁₁NO

[ 分子量 ]:
101.147

[ 闪点 ]:
23.9±0.0 °C

[ 精确质量 ]:
101.084061

[ PSA ]:
12.47000

[ LogP ]:
-0.33

[ 外观性状 ]:
透明液体

[ 蒸汽密度 ]:
>1 (vs air)

[ 蒸汽压 ]:
20.2±0.2 mmHg at 25°C

[ 折射率 ]:
1.435

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 水溶解性 ]:
>500 g/L (20 ºC)

N-甲基吗啉MSDS

详细MSDS(安全技术说明书)

N-甲基吗啉毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QE5775000

CHEMICAL NAME :: Morpholine, 4-methyl-

CAS REGISTRY NUMBER :: 109-02-4

LAST UPDATED :: 199710

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C5-H11-N-O

MOLECULAR WEIGHT :: 101.17

WISWESSER LINE NOTATION :: T6N DOTJ A1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 6/30/1959

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 6/30/1959

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,888,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1960 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,85,1982

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2000 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 31,60,1949

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1970 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 15,116,1979

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25200 mg/m3/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 15,116,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1350 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 31,60,1949

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1917 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 39(4),86,1974 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 5 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 5 ppm (20 mg/m3);STEL 10 ppm (40 mg/m3);Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0796 No. of Facilities: 123 (estimated) No. of Industries: 6 No. of Occupations: 8 No. of Employees: 1453 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0796 No. of Facilities: 212 (estimated) No. of Industries: 6 No. of Occupations: 6 No. of Employees: 3141 (estimated) No. of Female Employees: 125 (estimated)

N-甲基吗啉安全信息

[ 符号 ]:

GHS02, GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302-H314

[ 警示性声明 ]:
P210-P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R11;R20/21/22;R34

[ 安全声明 (欧洲) ]:
S16-S26-S36/37/39-S45-S25

[ 危险品运输编码 ]:
UN 2535 3/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
QE5775000

[ 包装等级 ]:
II

[ 危险类别 ]:
3

[ 海关编码 ]:
2934999090

N-甲基吗啉合成路线

详细合成路线

N-甲基吗啉上下游产品

N-甲基吗啉上游产品

N-甲基吗啉下游产品

N-甲基吗啉制备

1.由吗啉与甲醛、甲酸反应而得。将甲醛慢慢加入吗啉中，在搅拌下滴加甲酸，反应自动回流并放出二氧化碳。加完甲酸后，加热回流4-5h。冷却后加入氢氧化钠立即蒸馏，收集小于99℃的全部馏分，加入氢氧化钠至饱和，冷却分出油层，干燥，分馏，收集114.5-117℃馏分即为成品。另一种方法以二氯乙醚、一甲胺水溶液、液碱等搂原料，一步法合成，流程短，设备简单，工艺条件温和，投次少，产品收率高，质量好。

N-甲基吗啉海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

N-甲基吗啉文献

Hairpin assembly circuit-based fluorescence cooperative amplification strategy for enzyme-free and label-free detection of small molecule.

Talanta 143 , 101-6, (2015)

Here, we developed an enzyme-free, label-free, and sensitive fluorescence cooperative amplification strategy based on a hairpin assembly circuit which coupled catalytic hairpin assembly (CHA) with hyb...

Bioluminescent liquid light guide pad biosensor for indoor air toxicity monitoring.

Anal. Chem. 87(7) , 3655-61, (2015)

Indoor air pollution became a recent concern found to be oftentimes worse than outdoor air quality. We developed a tool that is cheap and simple and enables continuous monitoring of air toxicity. It i...

Acidosis increases MHC class II-restricted presentation of a protein endowed with a pH-dependent heparan sulfate-binding ability.

J. Immunol. 194(8) , 3601-11, (2015)

Heparan sulfate proteoglycans (HSPGs) are ubiquitously expressed molecules that participate in numerous biological processes. We previously showed that HSPGs expressed on the surface of APCs can serve...

更多文献