garenoxacin mesylate

更新时间：2024-01-14 16:46:01

garenoxacin mesylate结构式	常用名	garenoxacin mesylate	英文名	garenoxacin mesylate
	CAS号	223652-82-2	分子量	522.52
	密度	1.421g/cm3	沸点	581.5ºC at 760mmHg
	分子式	C₂₄H₂₄F₂N₂O₇S	熔点	N/A
	MSDS	N/A	闪点	305.5ºC

garenoxacin mesylate用途

甲磺酸加诺沙星(BMS 284756)是一种口服活性喹诺酮类抗生素,对多种革兰氏阳性和革兰氏阴性细菌、厌氧菌具有广谱活性。甲磺酸加诺沙星还抑制Gyrase和TOPO IV[1][2][3][4]。

英文名	garenoxacin mesylate
英文别名	更多

描述	甲磺酸加诺沙星(BMS 284756)是一种口服活性喹诺酮类抗生素,对多种革兰氏阳性和革兰氏阴性细菌、厌氧菌具有广谱活性。甲磺酸加诺沙星还抑制Gyrase和TOPO IV[1][2][3][4]。
相关类别	信号通路 >> 细胞周期/DNA损伤 >> 拓扑异构酶研究领域 >> 感染信号通路 >> 抗感染 >> 细菌
靶点	1.25 μg/mL (Gyrase), 1.5-2.5 μg/mL (TOPO IV)[2]
参考文献	[1]. Waites KB, et al. In vitro susceptibilities to and bactericidal activities of garenoxacin (BMS-284756) and other antimicrobial agents against human mycoplasmas and ureaplasmas. Antimicrob Agents Chemother. 2003 Jan;47(1):161-5. [2]. Ince D, et al. Dual targeting of DNA gyrase and topoisomerase IV: target interactions of garenoxacin (BMS-284756, T-3811ME), a new desfluoroquinolone. Antimicrob Agents Chemother. 2002 Nov;46(11):3370-80. [3]. Zhao X, et al. Mutant prevention concentration of garenoxacin (BMS-284756) for ciprofloxacin-susceptible or -resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2003 Mar;47(3):1023-7. [4]. Azoulay-Dupuis E, et al. Activities of garenoxacin against quinolone-resistant Streptococcus pneumoniae strains in vitro and in a mouse pneumonia model. Antimicrob Agents Chemother. 2004 Mar;48(3):765-73.

密度	1.421g/cm3
沸点	581.5ºC at 760mmHg
分子式	C₂₄H₂₄F₂N₂O₇S
分子量	522.52
闪点	305.5ºC
精确质量	522.12700
PSA	143.31000
LogP	5.38080

Garenoxacin Mesilate