描述 |
TP-030-1是RIPK1的抑制剂。TP-030-2抑制hRIPK1,Ki值为3.9nM,抑制mRIPK1(IC50值为4.2μM)。TP-030-1可用于炎症性疾病和神经退行性疾病的研究[1]。
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相关类别 |
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体外研究 |
TP-030-1以18nM的IC50值抑制HT29坏死[1]。TP-030-1以3.9nM的Ki值抑制hRIPK1[1]。TP-030-1以4.2μM的IC50值抑制mRIPK1[1]。
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参考文献 |
[1]. Msato Yoshikawa, et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure–Kinetic Relationships. J. Med. Chem. 2018, 61, 6, 2384–2409.
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