N-(3-Chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide
Modify Date: 2023-01-17 15:22:54
N-(3-Chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide structure
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Common Name | N-(3-Chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide | ||
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| CAS Number | 836640-15-4 | Molecular Weight | 403.86 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H18ClN3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of N-(3-Chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamidePARP1-IN-8 (compound 11c) is a potent and BBB-penetrated PARP1 inhibitor, with an IC50 of 97 nM. PARP1-IN-8 shows significantly potent anti-proliferative activity against Human lung adenocarcinoma epithelial cell line A549[1]. |
| Name | PARP1-IN-8 |
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| Description | PARP1-IN-8 (compound 11c) is a potent and BBB-penetrated PARP1 inhibitor, with an IC50 of 97 nM. PARP1-IN-8 shows significantly potent anti-proliferative activity against Human lung adenocarcinoma epithelial cell line A549[1]. |
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| Related Catalog | |
| Target |
PARP-1:97 nM (IC50) |
| In Vitro | PARP1-IN-8 (compound 11c) (0-10 μM, 24-48 h) shows significantly potent anti-proliferative activity against A549 cells[1]. Cell Proliferation Assay Cell Line: A549, HFF cells[1] Concentration: 0, 0.1, 1, 10 μM Incubation Time: 24, 48 h Result: Showed significantly potent anti-proliferative activity against A549 cells, and didn’t display any significant cytotoxicity on HFF cells[1]. |
| References |
| Molecular Formula | C23H18ClN3O2 |
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| Molecular Weight | 403.86 |