CSF1R-IN-15

Modify Date: 2024-01-06 18:15:40

CSF1R-IN-15 Structure
CSF1R-IN-15 structure
Common Name CSF1R-IN-15
CAS Number 2925744-43-8 Molecular Weight 358.44
Density N/A Boiling Point N/A
Molecular Formula C22H22N4O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CSF1R-IN-15


CSF1R-IN-15 (compound 23) is an inhibitor targeting CSF1R. The colony-stimulating factor-1 receptor (CSF1R) is a tyrosine kinase embedded in the cell membrane of macrophages. The receptor is activated by colony-stimulating factor-1 (CSF-1) and interleukin-34, and signaling via CSF1R is crucial for the differentiation, proliferation, and survival of macrophages[1].

 Names

Name CSF1R-IN-15

 CSF1R-IN-15 Biological Activity

Description CSF1R-IN-15 (compound 23) is an inhibitor targeting CSF1R. The colony-stimulating factor-1 receptor (CSF1R) is a tyrosine kinase embedded in the cell membrane of macrophages. The receptor is activated by colony-stimulating factor-1 (CSF-1) and interleukin-34, and signaling via CSF1R is crucial for the differentiation, proliferation, and survival of macrophages[1].
Related Catalog
References

[1]. Aarhus TI, et al. Synthesis and Development of Highly Selective Pyrrolo[2,3-d]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form. J Med Chem. 2023 May 25;66(10):6959-6980.  

 Chemical & Physical Properties

Molecular Formula C22H22N4O
Molecular Weight 358.44
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