CSF1R-IN-15

Names

[ CAS No. ]:
2925744-43-8

[ Name ]:
CSF1R-IN-15

Biological Activity

[Description]:

CSF1R-IN-15 (compound 23) is an inhibitor targeting CSF1R. The colony-stimulating factor-1 receptor (CSF1R) is a tyrosine kinase embedded in the cell membrane of macrophages. The receptor is activated by colony-stimulating factor-1 (CSF-1) and interleukin-34, and signaling via CSF1R is crucial for the differentiation, proliferation, and survival of macrophages[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Fms

[References]

[1]. Aarhus TI, et al. Synthesis and Development of Highly Selective Pyrrolo[2,3-d]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form. J Med Chem. 2023 May 25;66(10):6959-6980.  

Chemical & Physical Properties

[ Molecular Formula ]:
C22H22N4O

[ Molecular Weight ]:
358.44

Related Compounds

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