2925744-43-8

2925744-43-8 structure

Name: CSF1R-IN-15
Chemical Name: CSF1R-IN-15
CAS Number: 2925744-43-8
Molecular Formula: C₂₂H₂₂N₄O
Molecular Weight: 358.44
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK c-Fms
Create Date: 2023-09-28 19:05:02
Modify Date: 2024-01-06 18:15:40
CSF1R-IN-15 (compound 23) is an inhibitor targeting CSF1R. The colony-stimulating factor-1 receptor (CSF1R) is a tyrosine kinase embedded in the cell membrane of macrophages. The receptor is activated by colony-stimulating factor-1 (CSF-1) and interleukin-34, and signaling via CSF1R is crucial for the differentiation, proliferation, and survival of macrophages[1].

Name	CSF1R-IN-15

Description	CSF1R-IN-15 (compound 23) is an inhibitor targeting CSF1R. The colony-stimulating factor-1 receptor (CSF1R) is a tyrosine kinase embedded in the cell membrane of macrophages. The receptor is activated by colony-stimulating factor-1 (CSF-1) and interleukin-34, and signaling via CSF1R is crucial for the differentiation, proliferation, and survival of macrophages[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Fms
References	[1]. Aarhus TI, et al. Synthesis and Development of Highly Selective Pyrrolo[2,3-d]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form. J Med Chem. 2023 May 25;66(10):6959-6980.

Molecular Formula	C₂₂H₂₂N₄O
Molecular Weight	358.44