Ac-Exatecan

Modify Date: 2024-03-04 12:35:51

Ac-Exatecan structure	Common Name	Ac-Exatecan
	CAS Number	2922852-48-8	Molecular Weight	477.48
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₂₄FN₃O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Ac-Exatecan

Ac-Exatecan is acetylated Exatecan (HY-13631). Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM)[1].

Name	Ac-Exatecan

Description	Ac-Exatecan is acetylated Exatecan (HY-13631). Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin
References	[1]. Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82.

Molecular Formula	C₂₆H₂₄FN₃O₅
Molecular Weight	477.48

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Ac-Exatecan

Use of Ac-Exatecan

Names

Ac-Exatecan Biological Activity

Chemical & Physical Properties