Ac-Exatecan

Names

[ Name ]:
Ac-Exatecan

Biological Activity

[Description]:

Ac-Exatecan is acetylated Exatecan (HY-13631). Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin

[References]

[1]. Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₄FN₃O₅

[ Molecular Weight ]:
477.48

Related Compounds

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