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2922852-48-8

2922852-48-8 structure

2922852-48-8 structure

Name: Ac-Exatecan
Chemical Name: Ac-Exatecan
CAS Number: 2922852-48-8
Molecular Formula: C₂₆H₂₄FN₃O₅
Molecular Weight: 477.48
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Cytotoxin
Create Date: 2024-03-04 12:35:51
Modify Date: 2025-09-05 00:45:16
Ac-Exatecan is acetylated Exatecan (HY-13631). Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM)[1].

Name	Ac-Exatecan

Description	Ac-Exatecan is acetylated Exatecan (HY-13631). Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin
References	[1]. Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82.

Molecular Formula	C₂₆H₂₄FN₃O₅
Molecular Weight	477.48

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