CDK9-IN-14

Modify Date: 2024-01-14 12:53:43

CDK9-IN-14 Structure
CDK9-IN-14 structure
Common Name CDK9-IN-14
CAS Number 2650640-17-6 Molecular Weight 419.42
Density N/A Boiling Point N/A
Molecular Formula C21H23F2N3O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CDK9-IN-14


CDK9-IN-14 is a potent and selective CDK9 inhibitor with IC50 of 6.92 nM. CDK9-IN-14 has a relatively strong inhibitory effect on MV4;11 cells and in vivo tumor models, and has a good selectivity and a low toxicity and few side effects[1].

 Names

Name CDK9-IN-14

 CDK9-IN-14 Biological Activity

Description CDK9-IN-14 is a potent and selective CDK9 inhibitor with IC50 of 6.92 nM. CDK9-IN-14 has a relatively strong inhibitory effect on MV4;11 cells and in vivo tumor models, and has a good selectivity and a low toxicity and few side effects[1].
Related Catalog
Target

CDK9:6.92 nM (IC50)

In Vitro CDK9-IN-14 (0-1000 nM) has strong inhibitory effect in MV4;11 cells with IC50 = 34 nM[1].
In Vivo CDK9-IN-14 (5 mg/kg; p.o., qd, for 9 days) exhibits significant anti-tumor effect with tumor growth inhibition (TGI) value of 58%[1]. Animal Model: Female Nu/Nu mice (6-8 weeks old, 18-22 g, injected with HL-60 cells)[1] Dosage: 5 mg/kg Administration: p.o., qd, for 9 days Result: Exhibited significant anti-tumor effect with tumor growth inhibition (TGI) value of 58%.
References

[1]. WANG Zhenyu. Compound as cyclin-dependent kinase 9 inhibitor and use thereof. WO2021115335A1

 Chemical & Physical Properties

Molecular Formula C21H23F2N3O4
Molecular Weight 419.42