PROTAC ERRα Degrader-3
Modify Date: 2024-01-09 19:08:48
PROTAC ERRα Degrader-3 structure
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Common Name | PROTAC ERRα Degrader-3 | ||
|---|---|---|---|---|
| CAS Number | 2306388-65-6 | Molecular Weight | 956.99 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C47H50F6N6O7S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PROTAC ERRα Degrader-3PROTAC ERRα Degrader-3 is a potent and selective ERRα degrader based on PROTAC. PROTAC ERRα Degrader-3 is capable of specifically degrading ERRα protein by >80% at a concentration of 30 nM. PROTAC ERRα Degrader-3 is inactive against ERRβ and ERRγ proteins[1]. |
| Name | PROTAC ERRα Degrader-3 |
|---|
| Description | PROTAC ERRα Degrader-3 is a potent and selective ERRα degrader based on PROTAC. PROTAC ERRα Degrader-3 is capable of specifically degrading ERRα protein by >80% at a concentration of 30 nM. PROTAC ERRα Degrader-3 is inactive against ERRβ and ERRγ proteins[1]. |
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| Related Catalog | |
| Target |
ERRα VHL |
| In Vitro | PROTAC ERRα Degrader-3 (compound 6c; 0.3 nM-10 μM; 4 hours) dose-dependently induces ERRα degradation with an efficacious dose as low as 3.0 nM at 4.0 h. PROTAC ERRα Degrader-3 potently decreases protein levels of ERRα downstream target genes, e.g., ATP5B, medium-chain acyl CoA dehydrogenase (MCAD), and pyruvate dehydrogenase kinase 4 (PDK4) in the MDA-MB-231 cells after a 24 h treatment[1]. PROTAC ERRα Degrader-3 exhibits an IC50 value of 12.67 nM to block the protein-protein interaction of ERRα with PGC-1α peptide and induces approximately 96% protein degradation at 100 nM (D100 nM) after 4.0 h treatment[1]. Western Blot Analysis[1] Cell Line: MDA-MB-231 cells Concentration: 0.3 nM, 1 nM, 3 nM, 10 nM, 30 nM, 100 nM, 300 nM, 1 μM, 3 μM, 10 μM Incubation Time: 4 hours Result: Dose-dependently induced ERRα degradation. |
| References |
| Molecular Formula | C47H50F6N6O7S |
|---|---|
| Molecular Weight | 956.99 |
| Storage condition | -20°C |